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High Specific Activity Sm-153 by Post Irradiation Isotope Separation

Award Information

Agency:
Department of Energy
Branch:
N/A
Award ID:
Program Year/Program:
2012 / SBIR
Agency Tracking Number:
97861
Solicitation Year:
2012
Solicitation Topic Code:
46 b
Solicitation Number:
DE-FOA-0000676
Small Business Information
IsoTherapeutics Group LLC
1004 S. Velasco Angleton, TX 77515-5250
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 2012
Title: High Specific Activity Sm-153 by Post Irradiation Isotope Separation
Agency: DOE
Contract: DE-FG02-11ER90169
Award Amount: $989,748.00
 

Abstract:

Samarium-153 (153Sm) has ideal nuclear properties for a variety of therapeutic applications; however, it is only available in low specific activity (radioactivity/weight) form. While large quantities can be made by the 152Sm(n,)153Sm reaction in a medium flux reactor such as at the University of Missouri Research Reactor Center (MURR), typical irradiation parameters result in less than 2% of the 152Sm target material being converted into 153Sm. Since chemical methods cannot be used to perform isotopic separation, this means that & gt;98% of the resultant pharmaceutical molecules are labeled with cold atoms and are therefore incapable of delivering the desired radiation-induced therapeutic effect. Electromagnetic isotope separation is routinely used in the production of enriched stable isotopes and in mass spectrometry; however, the successful development of an economically viable facility for processing relatively short-lived radioactive medical isotopes presents new challenges. Results of the Phase I project clearly indicate the technical feasibility of using this approach for processing 153Sm. Experimental ion source testing demonstrated high extracted Sm+ ion current, in excess of 1 mA. All key process steps were tested individually, including pre- and post- separation chemistry.

Principal Investigator:

Jaime Simon
Dr.
979-848-0800
jimsimon@isotherapeutics.com

Business Contact:

R. K. Frank
Dr.
979-848-0800
keithfrank@isotherapeutics.com
Small Business Information at Submission:

Isotherapeutics Group LLC
1004 S. Velasco Angleton, TX 77515-5250

EIN/Tax ID: 203863390
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No