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Off-the-shelf Dental Regeneration Technologies

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
Program Year/Program:
2012 / SBIR
Agency Tracking Number:
R44DE019748
Solicitation Year:
2012
Solicitation Topic Code:
NIDCR
Solicitation Number:
PA11-096
Small Business Information
INNOVATIVE ELEMENTS, LLC
560 Sylvan Ave STE 3160 Englewood Cliffs, NJ -
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 2
Fiscal Year: 2012
Title: Off-the-shelf Dental Regeneration Technologies
Agency: HHS
Contract: 2R44DE019748-02A1
Award Amount: $665,015.00
 

Abstract:

DESCRIPTION (provided by applicant): Dentin forms the bulk of the tooth and is covered by enamel in the crown of the tooth and cementum in the root. When dental caries breaks down enamel and involves the dentin, the patient experiences pain and thermal sensitivity. The acute phase of dental pulp infection is typically associated with excruciating pain, and if not properly managed, can lead to peri-apical infection, tooth loss, facial infection and even systemic infections such as endocardiomyotis. Currentdental treatments for tooth decay rely on surgical removal of decayed enamel and dentin by dental instruments and filling of the prepared cavity with artificial materials including amalgam and composite resin. However, current restorative dental treatmentsby artificial fillers have finite service life and can fail unpredictably. Tooth fracture and secondary infections are among some of the well documented complications of current dental and endodontic treatments. Treatment options are further limited for deciduous teeth and young permanent teeth. We have discovered that dentin-like tissues can regenerate by bioactive scaffold formulations in our SBIR Phase I related work. The overall goal of this SBIR/Phase-2 proposal is to identify and prepare efficaciousand safe bioactive scaffold formulations for the regeneration of dentin-like tissues. This SBIR-Phase 2 represents essential intermediate funding to advance our technologies to the next stage of commercialization and eventually into a product that can ultimately regenerate dentin in patients who suffer from dental pain, trauma and infections. PUBLIC HEALTH RELEVANCE: Dental caries breaks down enamel and dentin, causing pain and infections. Current dental treatments for tooth decay rely on surgical removal of decayed enamel and dentin and filling of the prepared cavity with artificial materials. We have designed a technology to regenerate dentin-like structures that may be ultimately applicable to patients who suffer from dental pain, trauma and infections.

Principal Investigator:

Susan Fu
201-560-7181
sfu868@gmail.com

Business Contact:

Susan Fu
201-560-7312
sfu868@gmail.com
Small Business Information at Submission:

INNOVATIVE ELEMENTS, LLC
560 Sylvan Ave STE 3160 Englewood Cliffs, NJ -

EIN/Tax ID: 180951235
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No