USA flag logo/image

An Official Website of the United States Government

Company Information:

Address: 3181 SW SAM JACKSON PARK RD, L321
PORTLAND, OR 97239-3098
Located in HUBZone: No
Woman-Owned: No
Minority-Owned: No
Phone: N/A

Award Totals:

Program/Phase Award Amount ($) Number of Awards
SBIR Phase I $230,670.00 1
STTR Phase I $537,870.00 2
STTR Phase II $773,666.00 1

Award List:

In vivo expansion of human hepatocytes in Fah-/-Rag-/-Il2rg-/- mice

Award Year / Program / Phase: 2010 / STTR / Phase I
Agency: HHS
Research Institution: Oregon Health And Science University
Principal Investigator: Markus Grompe – 503-494-6888
Award Amount: $325,496.00
RI Contact:
DESCRIPTION (provided by applicant): The liver is the site of many metabolic processes, including metabolism of xenobiotics such as pharmaceutical compounds. Drug metabolism is highly species specific and can vary significantly between individuals of the same species. To date no reliable… More

FAH-Deficient Pigs

Award Year / Program / Phase: 2011 / STTR / Phase I
Agency: HHS
Research Institution: MAYO CLINIC
Principal Investigator: Scott L. Nyberg – 507-266-6772
Award Amount: $212,374.00
RI Contact:
DESCRIPTION (provided by applicant): Translational research in the field of liver disease has been limited by a shortage of large animal models, which in turn has limited development of new therapies for metabolic liver disorders, acute liver failure, chronic (cirrhotic) liver disease, an… More

In Vivo Expansion of Human Hepatocytes in FRG Mice

Award Year / Program / Phase: 2011 / STTR / Phase II
Agency: HHS
Principal Investigator: Markus Grompe – (503) 494-6888
Award Amount: $773,666.00
RI Contact: N/A
DESCRIPTION (provided by applicant): The FDA requires the use of human hepatocytes for preclinical drug testing by pharmaceutical researchers, but unfortunately the supply of these cells is severely limited. Currently, cadaveric donors and surgical liver resection specimens are currently the only… More

Double Humanization of Liver and Blood in Mice

Award Year / Program / Phase: 2012 / SBIR / Phase I
Agency: HHS
Principal Investigator: Elizabeth M. Wilson – 503-941-5076
Award Amount: $230,670.00
DESCRIPTION (provided by applicant): Chimeric mice with highly humanized livers have multiple potential applications in research and preclinical drug development both in the academic and commercial settings [1]. The applications include studies of human infectious diseases (hepatitis B and B,… More