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Customized Nanofiltration Membranes for Enhancing Pharmaceutical Manufacturing

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
Program Year/Program:
2011 / SBIR
Agency Tracking Number:
R43GM093710
Solicitation Year:
2011
Solicitation Topic Code:
NIGMS
Solicitation Number:
PA10-050
Small Business Information
Compact Membrane Systems, Inc.
335 Water Street Newport, DE 19804-2410
View profile »
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 2011
Title: Customized Nanofiltration Membranes for Enhancing Pharmaceutical Manufacturing
Agency: HHS
Contract: 1R43GM093710-01A1
Award Amount: $161,657.00
 

Abstract:

DESCRIPTION (provided by applicant): The overall focus of this application is to develop nanofiltration membranes to recover the spent solvents generated from drug manufacturing processes allowing the solvents to be reused resulting in elimination of waste. This is also responsive to NIH RFP PA-09-100 entitled Energy Efficiency and Renewable Energy System Technology Research and Development . By using a pressure-driven nanofiltration versus a thermal-driven separation such as distillation for recovery of pharmaceutical spent solvents, we also are directly responsive to this NIH's RFP for energy efficient processes. Chemical syntheses in the pharmaceutical industry are often carried out in solvents and generate large amount of spent solvents. Extraction andpurification of pharmaceutical ingredients and cleaning of the drug manufacturing equipment such as reactors also generate solvent effluents. There are numerous needs in the pharmaceutical industry that involve the treatment of these organic solvents. They include: i) production of high purity solvents for organic synthesis ii) recovery of spent organic solvents to reduce the amount of toxic waste produced. The current application is addressed to remove contaminants from spent organic solvents generated from the production of bulk pharmaceutical substances. Nanofiltration separation, driven by the applied pressure gradient, allows solvents to permeate selectively through the membrane retaining the solutes and non-selective solvents. Most of the waste solvents produced in the drug manufacturing processes contain low molecular compounds or solutes such as spent catalysts and by-products with molecular weight less than 1000 g/mol. The spent solvents often contain azeotropic solvent mixtures that can not be separated easily. PUBLIC HEALTH RELEVANCE: This project will develop a membrane product and process to remove dissolved oxygen and water from reaction solvents and reactants as well as unreacted chemicals, spent catalysts and byproducts from spent organic solvents. This development has considerable significance to reduce production costs related to pharmaceutical manufacturing.

Principal Investigator:

Praveen B. Kosaraju
973-596-8457
pkosaraju@compactmembrane.com

Business Contact:

Stuart Nemser
302-999-7996
bkelley@compactmembrane.com
Small Business Information at Submission:

COMPACT MEMBRANE SYSTEMS, INC.
335 WATER STREET NEWPORT, DE 19804-

EIN/Tax ID: 151034825
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No