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ANTI-IDIOTYPIC VACCINES FOR AIDS

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 7859
Amount: $500,000.00
Phase: Phase II
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Timeline
Solicitation Year: N/A
Award Year: 1990
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
10301 Stella Link Rd
Houston, TX 77025
United States
DUNS: N/A
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 () -
Business Contact
Phone: () -
Research Institution
N/A
Abstract

THE GEOMETRIC INCREASE IN THE NUMBER OF INDIVIDUALS INFECTED BY HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (HIV-1) HAS CREATED SERIOUS SOCIAL, ECONOMICAL AND LIFE-THREATENING ISSUES TO THE HUMAN RACE. IT IS OF PRESSING CONCERNS TO DEVELOP EFFECTIVE MEASURES FOR CONTROLLING THE SPREAD OF THIS DISEASE, FAVORABLY BY INDUCING ACTIVE IMMUNITY TO THE INDIVIDUALS AT RISK TO THE INFECTION. BASED ON THE PHENOMENA OF IDIOTYPE (ID) NETWORKS IN THE ANTIBODY-MEDIATEDIMMUNE RESPONSE, WE NOW PROPOSE THE USE OF HIV-1 GROUP-SPECIFIC NEUTRALIZATION MONOCLONAL ANTIBODIES TO GENERATE MONOCLONAL ANTI-IDIOTYPIC ANTIBODIES (ANTI-ID) WHICH MIMIC THE NEUTRALIZATION EPITOPES OF THE VIRUS. THE LONG-TERM OBJECTIVE OF THE PROJECT IS TO DEVELOP SAFE AND EFFECTIVE ANTI-ID VACCINES TO PROTECT THE POPULATION FROM THE INFECTION, AND THUS TO ACHIEVE THE GOAL OF CONTROLLING THIS EPIDEMIC. THE SPECIFIC AIMS OF THIS PHASE I PROJECT ARE: (1) TO GENERATE HYBRIDOMAS WHICH SECRETE MONOCLONAL ANTI-ID'S BY IMMUNIZING MICE WITH THE NEUTRALIZATION MONOCLONAL ANTIBODIES, (2) TO IDENTIFY THE ANTI-ID'S WHICH MIMIC THE CONFORMATION OF THE EPITOPES RECOGNIZED BY THE NEUTRALIZATION ANTIBODIES.

* Information listed above is at the time of submission. *

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