Nitroxide Labeled Hemoglobin as a Blood Substitute

Award Information

Agency: Department of Health and Human Services	Branch: N/A	Award ID: 29514	Program Year/Program: 1995 / SBIR
Agency Tracking Number: 29514	Solicitation Year: N/A	Solicitation Topic Code: N/A	Solicitation Number: N/A

Small Business Information: SYNZYME TECHNOLOGY, INC.
1 TECHNOLOGY DR, B-115 IRVINE, CA 92618-
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Woman-Owned: No

Minority-Owned: No

HUBZone-Owned: Yes

Phase 1: Fiscal Year: 1995

Title: Nitroxide Labeled Hemoglobin as a Blood Substitute

Agency: HHS

Contract: 1 R43 HL53860-01,

Award Amount: $98,400.00

Abstract:
A number of biopharmaceutical companies have successfully taken hemoglobin-based oxygen carriers (Hinto phase I clinical trial. However, transfusions have been limited to low dosage levels due to obsvasoconstrictive effects at high dosage levels in pre-clinical animal studies. This proposal deals wfailure to have an oxidant detoxification system similar to the one which is intrinsic to the red blsubstitute. This research plan intends to modify a high- quality HBOC, which is currently in clinicathat stable nitroxide free radicals can be used to perform an oxidant detoxification function. If ththen the groundwork would established for a second generation red blood cell substitute which couldcommercialized.

Principal Investigator:
Carleton Hsia
71453

Business Contact:

Small Business Information at Submission:

Synzyme Technology, Inc.
1 Technology Drive, E-309 Irvine, CA 92718

EIN/Tax ID:

DUNS: N/A

Number of Employees: N/A

Woman-Owned: No

Minority-Owned: No

HUBZone-Owned: No