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MOLECULAR CAGES FOR ALPHA PARTICLE RADIOIMMUNOTHERAPY

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R43CA096356-01
Agency Tracking Number: CA096356
Amount: $99,998.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Timeline
Solicitation Year: N/A
Award Year: 2002
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
TDA RESEARCH, INC. 12345 W 52ND AVE
WHEAT RIDGE, CO 80033
United States
DUNS: N/A
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 MICHAEL DIENER
 (303) 940-2314
 MIKEE@TDA.COM
Business Contact
 JOHN WRIGHT
Phone: (303) 940-2300
Email: JDWRIGHT@TDA.COM
Research Institution
N/A
Abstract

Radioimmunotherapy (RIT) is a promising therapy for cancer, wherein radionuclides are linked to monoclonal antibodies specific for antigens expressed solely on tumor cells. Once the mAb locates the tumor cell, the radionuclide decays and kills the cell. The compounds that have so far undergone clinical trials are based on beta-emitting radionuclides, because they can be reliably linked to the mAb. However, alpha radiation has significant advantages for distributed carcinomas, including short path length and much greater cytotoxicity The development of alpha-emitting radionuclides has been severely hampered by a lack of robust chelates for radionuclides with therapeutically desirable half- lives. This project aims to develop a new encapsulate with 100% containment, suitable for all actinide radionuclides. PROPOSED COMMERCIAL APPLICATIONS: This encapsulate will enable alpha particle RIT methods to be developed for the treatment of leukemias, lymphomas, micrometastates, lung cancer, and other cancers where tumors are smaller than a few cell diameters. The development of such a therapy has a potential market of approximately 300,000 Americans/yr.

* Information listed above is at the time of submission. *

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