Clinical Reagents for Peripheral Blood Stem Cells
1 R43 HL53804-01,
We will develop fully defined, serum-free culture reagents, which contain no components of non- humwhich can be produced under completely controlled and reproducible pharmaceutical standards, and whiwith recombinant human hematopoietic factors will successfully support the generation and expansionprogenitor cells in-vitro from normal human marrow or blood mononuclear cells in short-term suspensidefine, develop and carry out initial preclinical evaluation of fully-defined, serum-free culture recomponents of non-human origin, to be used for culture of normal human hematopoietic progenitor cellbe to use successful serum-free reagents that have been shown to support hematopoietic stem cell expcontain components of non-human origin which will be sequentially replaced with components that areapproved. Development of these tissue culture reagents will focus on a specific clinical applicationand expansion of late neutrophil progenitors for infusion into patients undergoing autologous bone mblood stem cell transplantation in order to prevent or abate profound neutropenia in these patients.
Small Business Information at Submission:
Principal Investigator:Ronald Brown
Quality Biological, Inc.
7581 Lindbergh Drive Gaithersburg, MD 20879
Number of Employees: