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SERUM-FREE MEDIUM FOR HEMATOPOIETIC CELLS

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
7245
Program Year/Program:
1987 / SBIR
Agency Tracking Number:
7245
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
QUALITY BIOLOGICAL, INC.
QUALITY BIOLOGICAL, INC. 7581 LINDBERGH DRIVE GAITHERSBURG, MD 20879
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Woman-Owned: Yes
Minority-Owned: Yes
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1987
Title: SERUM-FREE MEDIUM FOR HEMATOPOIETIC CELLS
Agency: HHS
Contract: N/A
Award Amount: $49,000.00
 

Abstract:

THE LONG-TERM OBJECTIVE OF THIS PROPOSAL IS TO DEVELOP A SERUM-FREE MEDIUM THAT WILL SUPPORT THE GROWTH AND DIFFERENTIATION OF HEMATOPOIETIC CELLS. THE INITIAL RESEARCH WILL FOCUS ON THE DEVELOPMENT OF A SERUM-FREE MEDIUM THAT WILL SUPPORT THE GROWTH AND DIFFERENTIATION OF ERYTHROCYTES, GRANULOCYTES, MACROPHAGES, AND LYMPHOCYTES. SPECIFIC ATTENTION WILL BE PAID TO THE PURITY OF EACH COMPONENT AND ONLY HUMAN COMPOUNDS WILL BE USED WHERE BIOLOGICAL COMPONENTS ARE FOUND NECESSARY. SUCH STUDIES WILL EMPLOY THE IN VITRO ASSAYS THAT ARE ROUTINELY USED FOR HEMATOPOIETIC CELLS. THE INITIAL SERUM-FREE MEDIUM WILL BE DEVELOPED FOR THE PROLIFERATION OF NORMAL HUMAN PERIPHERAL BLOOD LYMPHOCYTES AND SUBSEQUENTLY MODIFIED FOR BONE MARROW CELLS. THIS APPROACH SHOULD NOT ONLY LEAD TO THE DEVELOPMENT OF A SERUM-FREE MEDIUM BUT ELUCIDATE THE ROLE EACH COMPONENT PLAYS IN HEMATOPOIESIS. PHASE I WILL PRIMARILY USE ERYTHROCYTES, GRANULOCYTES, AND MACROPHAGES TO GAIN AN UNDERSTANDING OF THE COMPONENTS THAT WILL SUPPORT PROLIFERATION AND DIFFERENTIATION OF HEMATOPOIETIC CELLS. PHASE II WILL EXTEND THIS EFFORT TO DEVELOP A SERUM-FREE MEDIUM FOR ALL THE HUMAN HEMATOPOIETIC CELLS. SUCH A MEDIUM WILL BE USEFUL FOR STANDARDIZING IN VITRO HEMATOPOIETIC ASSAYS AND TRANSPLANTATION STUDIES WHERE SPECIFIC BONE MARROW POPULATIONS NEED TO BE EXPANDED.

Principal Investigator:

Ronald l brown
3018409331

Business Contact:

Small Business Information at Submission:

Quality Biological Inc
7920 Queenair Drive Gaithersburg, MD 20879

EIN/Tax ID:
DUNS: N/A
Number of Employees: N/A
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No