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SERUM-FREE MEDIUM FOR LAK AND NATURAL KILLER CELLS AND MONOCYTES

Award Information

Agency:
Department of Health and Human Services
Branch:
N/A
Award ID:
7934
Program Year/Program:
1988 / SBIR
Agency Tracking Number:
7934
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
QUALITY BIOLOGICAL, INC.
QUALITY BIOLOGICAL, INC. 7581 LINDBERGH DRIVE GAITHERSBURG, MD 20879
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Woman-Owned: Yes
Minority-Owned: Yes
HUBZone-Owned: No
 
Phase 1
Fiscal Year: 1988
Title: SERUM-FREE MEDIUM FOR LAK AND NATURAL KILLER CELLS AND MONOCYTES
Agency: HHS
Contract: N/A
Award Amount: $50,000.00
 

Abstract:

THE LONG RANGE GOAL OF THE PROPOSED RESEARCH IS TO DEVELOP SERUM-FREE MEDIA FORMULATIONS FOR THE CULTURE OF HUMAN LEUKOCYTES IN VITRO. THE OBJECTIVE OF PHASE I STUDIES IS TODEVELOP SERUM-FREE MEDIUM THAT WOULD ALLOW MAXIMUM GROWTH AND CYTOTOXIC ACTIVITY OF NON-MITOGEN ACTIVATED HUMAN LYMPHOKINE ACTIVATED KILLER CELLS, NATURAL KILLER CELLS, MONOCYTES AND MITOGEN ACTIVATED CYTOTOXIC T CELLS. BASED ON PHASE I RESULTS, PHASE II STUDIES WILL CONCENTRATE ON PRODUCING SERUM-FREE MEDIUM FOR THE BATCH PRODUCTION OF CANCER PATIENT-DERIVED LEUKOCYTES FOR MEDICAL RESEARCH. THIS MEDIUM WOULD ALLEVIATE MANY OF THE PROBLEMS ASSOCIATED WITH CELL PROPAGATION IN THE PRESENCE OF ANIMAL SERA OR POOLED HUMAN SERA. THIS PHASE I PROPOSAL OUTLINES THE DEVELOPMENT OF A HIGH QUALITY SERUM-FREE MEDIUM UTILIZING BIOLOGICAL COMPONENTS DERIVED SOLELY FROM HUMAN SOURCES. THE COMPOSITION AND OPTIMAL CONCENTRATIONS OF EACH COMPONENT OF THE MEDIUM WILL BE SELECTED WITH PARTICULAR CONCERN FOR THE GROWTH AND MAINTENANCE OF HUMAN CELLS. BY CONSTROLLING THE EXTERNAL SIGNALS THE ROLE VARIOUS BIOLOGICAL RESPONSE MODIFIERS PLAY ON CYTOTOXIC ACTIVITY CAN BE CLEARLY EVALUATED.

Principal Investigator:


0

Business Contact:

Small Business Information at Submission:

Quality Biological Inc
7920 Queenair Dr Gaitherburg, MD 20879

EIN/Tax ID:
DUNS: N/A
Number of Employees:
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No