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IMMUNOASSAYS FOR MUTAGENIC AND CARCINOGENIC ADDUCTS IN HUMAN DNA

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 7163
Amount: $432,000.00
Phase: Phase II
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Timeline
Solicitation Year: N/A
Award Year: 1989
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
1858 Star Batt Dr
Rochester, MI 48063
United States
DUNS: N/A
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Cynthia L Sevilla Phd
 () -
Business Contact
Phone: () -
Research Institution
N/A
Abstract

DIFUNCTIONAL CARBONYL COMPOUNDS ARE TOXIC, MUTAGENIC, AND CARCINOGENIC AND ARE UBIQUITOUS CONTAMINANTS OF THE HUMAN ENVIRONMENT. THE SIMPLEST EXAMPLES OF SUCH COMPOUNDS ARE MALONDIALDEHYDE, ACROLEIN, AND METHYL GLYOXAL. MALONDIALDEHYDE IS A PRODUCT OF LIPID PEROXIDATION AND PROSTAGLANDIN BIOSYNTHESIS AND IS PRESENT IN VIRTUALLY ALL MAMMALIAN TISSUES. METHYL GLYOXAL IS ALSO A NATURAL PRODUCTAND IS PRESENT IN FRESHLY ROASTED COFFEE. ACROLEIN IS A MAJOR INDUSTRIAL STARTING MATERIAL AND IS PRESENT IN CIGARETTE SMOKE. ALL OF THESE COMPOUNDS ARE MUTAGENIC, AND METHYL GLYOXAL INDUCES SUBCUTANEOUS TUMORS WHEN INJECTED IN MICE. THE EXTENT TO WHICH DIFUNCTIONAL CARBONYL COMPOUNDS CONTRIBUTE TO HUMAN CANCER IS UNCERTAIN, BUT THERE CAN BE LITTLE DOUBT THAT EXPOSURE TO THESE COMPOUNDS IS CONSIDERABLE. WHILE IT IS THOUGHT THAT THESE COMPOUNDS EXERT THEIR MUTAGENIC AND CARCINOGENIC EFFECTS BY FORMING ADDUCTS WITH DNA, METHODS FOR ACCURATE DETERMINATION OF THESE ADDUCTS ARE NOT AVAILABLE. THE LONG-TERM GOALS OF THIS PROJECT ARE THE DEVELOPMENT OF MONOCLONAL ANTIBODIES SPECIFIC FOR THE MAJOR NUCLEIC ACID ADDUCTS OF THESE DIFUNCTIONAL CARBONYL COMPOUNDS, FOR USE IN ENZYME-LINKED IMMUNOSORBENT ASSAYS AND IN ASSAYS OF SPREAD DNA AND DNA IN NUCLEI. THESE ASSAYS WILL BE DEVELOPED FOR USE IN CLINICAL AND RESEARCH MONITORING OF LEVELS OF THESE ADDUCTS IN HUMAN DNA SAMPLES.

* Information listed above is at the time of submission. *

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