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IN SITU OPTICAL ANALYZER FOR COMPONENTS IN BIOREACTORS

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R43CA094633-01
Agency Tracking Number: CA094633
Amount: $102,964.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Timeline
Solicitation Year: N/A
Award Year: 2002
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
POLESTAR TECHNOLOGIES, INC. 220 RESERVOIR ST, STE 32
NEEDHAM HEIGHTS, MA 02494
United States
DUNS: N/A
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 RONALD MICHEELS
 (781) 449-2284
 RON@POLESTARTECH.COM
Business Contact
 KAREN CARPENTER
Phone: (781) 449-2284
Email: KCARPENTER@POLESTARTECH.COM
Research Institution
N/A
Abstract

An optically based instrument for in-situ analysis of multiple chemical components in bioreactors will be developed and applied to monitor key components in hybridoma cell fermentation processed used for producing monoclonal antibodies. Monoclonal antibodies have become valuable agents for new cancer therapy and diagnostic methods.. The in situ analyzer employs a novel design integrating recent advances in opto- electronic technology to provide a multiple component analyzer which eliminates interference from biofouling of exposed optical surfaces. The in situ probe design for multiple component analyzer will be compatible with steam sterilization. In the Phase I program, the cell density monitor will be calibrated and evaluated in a research bioreactor to simultaneously monitor one nutrient and one product compound in a hybridoma fermentation process. The in situ analyzer will find commercial applications in monitoring nutrients, products and undesirable byproducts for improved process control and productivity in industrial bioreactors used for production of monoclonal antibodies as well as other bio-pharmaceuticals. PROPOSED COMMERCIAL APPLICATIONS: Applications of the in-situ monitor would be monitoring of nutrients, products and byproducts in industrial bioreactors used for production of monoclonal antibodies, other biopharmaceuticals and commodity. This would include production, pilot and research scale bioreactors.

* Information listed above is at the time of submission. *

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