You are here

IN-SITU CELL DENSITY MONITOR FOR BIOREACTORS

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: N/A
Agency Tracking Number: 1R43GM062687-01
Amount: $99,970.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Timeline
Solicitation Year: N/A
Award Year: 2001
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
220 RESERVOIR ST, STE 32
NEEDHAM HEIGHTS, MA 02194
United States
DUNS: N/A
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 RONALD MICHEELS
 () -
Business Contact
Phone: (781) 449-2284
Email: POLESTAR@IX.NETCOM.COM
Research Institution
N/A
Abstract

In the Phase I program, an optically based instrument will be developed for in-situ
monitoring of cell density in bioreactors used for manufacturing biopharmaceuticals.
The cell density monitor employs a novel design integrating recent advances in
opto-electronic technology to provide a monitor, which eliminates interference from
both biofouling of exposed optical surfaces and aeration bubbles. Biofouling and
bubbles present substantial problems in existing commercial cell density
monitors. The in-situ probe design for the cell monitor will be compatible with
steam sterilization. In the Phase I program, the cell density monitor will find
commercial applications in improved process control for industrial bioreactors
used for producing biopharmaceuticals and commodity chemicals. The monitor
would lead to increased productivity for these industries.

PROPOSED COMMERCIAL APPLICATION:
The in-situ monitor would be utilized in monitoring cell density in industrial bioreactors
used for production of biopharmaceuticals and commodity chemicals, including production,
pilot, and research scale bioreactors.

* Information listed above is at the time of submission. *

US Flag An Official Website of the United States Government