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Improved Sensitivity in a Rapid, Label-Free Immunoassay using Liquid Crystals

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R43GM077811-01
Agency Tracking Number: GM077811
Amount: $453,621.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: PHS2006-2
Timeline
Solicitation Year: 2006
Award Year: 2006
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
PLATYPUS TECHNOLOGIES, LLC 5520 Nobel Drive, Suite 100
MADISON, WI 53711
United States
DUNS: N/A
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 BARBARA ISRAEL
 (608) 237-1270
 bisrael@platypustech.com
Business Contact
 SUSAN PSCHORR
Phone: (608) 237-1272
Email: SPSCHORR@PLATYPUSTECH.COM
Research Institution
N/A
Abstract

DESCRIPTION (provided by applicant): Liquid crystals can be used to image proteins on surfaces. In previous studies, we have shown that a combination of affinity contact printing techniques with liquid crystal imaging can form the basis for a rapid, label free detection technology, useful in the detection of antibodies. In this Phase 1 proposal, we undertake to increase the sensitivity of this approach to extend its usefulness to detection of low concentration molecules of clinical relevance, such as biomarkers and cytokines. We propose approaches that will permit detection of molecules present in solution at the pg/ml concentration. The success of this project will permit the development of high sensitivity, high density micro arrays based on liquid crystals for rapid, label free detection of low concentration molecules.

* Information listed above is at the time of submission. *

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