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Portable System for Deployment Toxicology

Award Information
Agency: Department of Defense
Branch: Air Force
Contract: FA8650-06-C-6647
Agency Tracking Number: F051-076-1534
Amount: $749,924.00
Phase: Phase II
Program: SBIR
Solicitation Topic Code: AF05-076
Solicitation Number: 2005.1
Timeline
Solicitation Year: 2005
Award Year: 2006
Award Start Date (Proposal Award Date): 2006-04-28
Award End Date (Contract End Date): 2008-05-28
Small Business Information
20 New England Business Center
Andover, MA 01810
United States
DUNS: 073800062
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 David Fenner
 Principal Research Scient
 (978) 689-0003
 fenner@psicorp.com
Business Contact
 B. Green
Title: President of R&D Operatio
Phone: (978) 689-0003
Email: green@psicorp.com
Research Institution
N/A
Abstract

The Phase I program at PSI has successfully met and exceeded its first goal by multiplexed assay of 12 cytokines in simulants and whole human saliva, at clinically significant concentrations as low as 5 pg/ml with microplate technology. A survey of the medical literature and communications with Dr. Wayne Ensign verified that the identity and concentrations of the cytokine assay was sufficient to diagnose immunological response to infection. The second goal was met by developing a complete design for a rugged and light weight microplate reader utilizing all commercial off-the-shelf (COTS) components. A Phase II program is proposed that will complete a small clinical study of saliva cytokine response to infection, make improvements to the microplate function and stability, complete the plate reader engineering and fabricate two prototypes. Specific advantages of the PSI approach are validation of the link from saliva cytokines to simple diagnosis, utilization of COTS components throughout, and the near-term prospect of a field worthy system for deployment to field hospitals. With Phase III development, diagnosis of chemical, biological and radiation exposure will be rapidly and accurately identified with diagnosis detail sufficient to know that there is a problem and distinguish stress from infection or other exposure.

* Information listed above is at the time of submission. *

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