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Microchannel Proteomic Array

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R43CA101274-01
Agency Tracking Number: CA101274
Amount: $99,991.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Timeline
Solicitation Year: N/A
Award Year: 2003
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
20600 GRAMERCY PLACE, BLDG. 100
TORRANCE, CA 90501
United States
DUNS: N/A
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 GREGORY ZELTSER
 (310) 320-3088
 SUTAMA@POC.COM
Business Contact
 GORDON DREW
Phone: (310) 320-3088
Email: GDREW@POC.COM
Research Institution
N/A
Abstract

DESCRIPTION (provided by applicant): Physical Optics Corporation (POC) proposes to design, develop, fabricate, and test a Microchannel Proteomic Array (MPA) system based on proprietary silicon chip fabrication technology and integration of immunodetection amplified by T7 RNA polymerase (IDAT) and fluorescence-in-situ-hybridization (FISH) techniques. The system will provide high throughput, precise isolation, and quantitative analysis of proteins in unpurified samples of body fluids and/or cancer cells, as well as allow carrying out protein-protein and protein-ligand interaction studies. The MPA system will consist of three components: a microarray chip, a POC backlit holographic diffuser screen, and a processing/analyzing subsystem. The chip will have up to 10,000 micro-channels on a 2. 25 cm2 plate surface and the potential to simultaneously assay ten thousand proteins/ oligopepetides in an unpurified sample in hours. The highly sensitive chip combined with a massively parallel, automated analysis array can yield ultrahigh throughput. The microchip will consume only nanoliters of the sample. In Phase I, POC will investigate micro-channel proteomic array system design and architecture to demonstrate proof-of-concept.

* Information listed above is at the time of submission. *

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