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Immunofluorometric Drug Detection System

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: N/A
Agency Tracking Number: 1R43DA014780-01
Amount: $99,992.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Timeline
Solicitation Year: N/A
Award Year: 2001
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
20600 GRAMERCY PL, BLDG 100
TORRANCE, CA 90501
United States
DUNS: N/A
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 GREGORY ZELTSER
 () -
Business Contact
Phone: (310) 320-3088
Email: GDREW@POC.COM
Research Institution
N/A
Abstract

DESCRIPTION (provided by applicant): Administration of drug testing in the
field requires a non-invasive drug assay that can be performed immediately at
the site of specimen collection. To address this need, POC proposes to design,
develop, and fabricate a unique saliva-based Immunofluorometric Drug Detection
System (IDDS) as a rapid, sensitive, and simple-to-use multi-analyte diagnostic
tool with disposable cartridges. The IDDS consists of two elements: a high
surface area cartridge and a fluorometric reader. The three-dimensional polymer
cartridge surface relief is covered with a patchwork of positively and
negatively charged binding sites to provide high immobilization density of
catching antibodies without steric inhibition. Additionally, this cartridge
significantly improves the sensitivity and robustness of the two-step
quantitative "sandwich" immunofluorometric assay of drugs in saliva performed
in a portable fluorometric reader. The IDDS device will be build on a base of
commercially available parts and will include a holographic cartridge. Phase I
will culminate in a full proof-of-concept demonstration using an in vitro
artificial model.
PROPOSED COMMERCIAL APPLICATION:
In addition to saliva-based drug detection, the IDDS device also can be used for detection of pathogens in body fluids; rapid immunoassay for hormones, medications, and metabolites; and military surveillance and and monitoring of biological and chemical warfare agents.

* Information listed above is at the time of submission. *

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