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IMPROVED THERAPY FOR CNS TOXOPLASMOSIS

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 11067
Amount: $50,000.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Timeline
Solicitation Year: N/A
Award Year: 1989
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
Box 730
Alachua, FL 32615
United States
DUNS: N/A
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 () -
Business Contact
Phone: () -
Research Institution
N/A
Abstract

CEREBRAL TOXOPLASMOSIS IS THE MOST COMMON OPPORTUNISTIC DISEASE AFFECTING THE BRAIN OF PATIENTS WITH ACQUIRED IMMUNEDEFICIENCY SYNDROME (AIDS). SULFONAMIDE TREATMENT IS INITIALLY EFFECTIVE IN TREATING THE INFECTION, BUT THE REGIMEN OFTEN CAUSES SIDE EFFECTS THAT LIMIT THERAPY, SUBSEQUENTLY PROVOKING RELAPSE. THIS RESEARCH SEEKS TO DEVELOP BRAIN-TARGETED DELIVERY FORMS OF THE ACTIVE ANTITOXOPLASMA AGENTS SUCH AS SULFADIAZINE. THE METHOD CHOSEN TO ACHIEVE SELECTIVITY IS A DIHYDROPYRIDINE = PYRIDINIUM SALT, REDOX-TYPE CHEMICAL DELIVERY SYSTEM (CDS). VARIOUS TYPES OF CDS'S WILL BE APPLIED TO THE SELECTED SULFA DRUGS. ANALYTICAL METHODOLOGIES WILL BE DEVELOPED FOR THE SYNTHESIZED COMPOUNDS. IN VITRO EXAMINATIONS, INCLUDING LIPOPHILICITY DETERMINATION AND COMPOUND STABILITY BOTH IN CHEMICAL OXIDANTS AND IN BIOLOGICAL MATRICES, WILL HELP TO SELECT A CDS FOR IN VIVO EXPERIMENTATION. A DISTRIBUTION STUDY IN RATS WILL INDICATE WHETHER THE CDS SATISFACTORILY PERFORMED ITS FUNCTION AS MEASURED BY BRAIN RETENTION OF SULFONAMIDE ANTIBIOTIC RELATIVE TO PERIPHERAL RETENTION. PROPERLY DEVELOPED, A CDS FOR SULFONAMIDE COULD IMPROVE THE THERAPY OF TOXOPLASMOSIS BY DIVERTING A LARGER PORTION OF THE ADMINISTERED DOSE TO THE SITE OF INFECTION AND REDUCE TOXICITIES THAT ARE OFTEN DOSE LIMITING.

* Information listed above is at the time of submission. *

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