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MR Elastrography for Breast Cancer Detection

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R43CA101241-01
Agency Tracking Number: CA101241
Amount: $99,820.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Timeline
Solicitation Year: N/A
Award Year: 2003
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
P.O. BOX 71 16 GREAT HOLLOW ROAD
HANOVER, NH 03755
United States
DUNS: 072021041
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 ROBERT KLINESCHODER
 (603) 643-3800
 RJK@CREARE.COM
Business Contact
 PAUL ROTHE
Phone: (603) 643-3800
Email: WRB@CREARE.COM
Research Institution
N/A
Abstract

DESCRIPTION (provided by applicant):
Breast cancer is the most commonly diagnosed cancer in women. Early diagnosis, which is critical for favorable clinical outcomes, is complicated by the difficulty of detecting small tumors. One physical property that clearly distinguishes healthy from cancerous tissue is mechanical stiffness (hardness). For this reason, palpation has long been used for early screening. Researchers have attempted to combine external mechanical stimulation and Magnetic Resonance Imaging (MRI) to quantitatively measure the Young's modulus (i.e., stiffness) of tissue throughout both the breast and the prostate. This technique, Magnetic Resonance Elastography (MRE), has been called "palpation at a distance." The most challenging technical issue associated with MRE is the solution of the "inverse problem," i.e., quantitatively inferring Young's modulus from MRI-measured tissue displacement data.

The specific aim of this project is to develop methods and devices for enhancing breast cancer detection and diagnosis using MRE. To achieve this aim, we will develop analytical solution techniques to improve the efficiency and robustness of the inverse problem solution and design and implement a realistic clinical system.

* Information listed above is at the time of submission. *

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