65755 Recent efforts employing bioorganisms to remediate landfills contaminated with heavy metals and radionuclides are hampered by the innability to characterize the oxidation state of these contaminants. This project will develop technology for the rapid, in-situ, ppb detection,… More

In 1999 the FDA reported that as much as 1% of food brought to market may have contained pesticide residues exceeding EPA tolerance levels (sub part-per-million concentrations) set for safe consumption. The uncertainty in this value is due to the long analysis times (hours/sample) that limit the… More

"The overall goal of this proposed program is to develop fiber optic Raman spectroscopy as an on-line analyzer capable of optimizing the mechanical properties of composites during manufacture. Phase I will demonstrate feasibility by developingrelationships between reaction mechanisms measured by… More

This Small Business Innovation Research Phase I Project proposes to develop a real-time anthrax (Bacillus anthracis) detector for mail-sorting systems. The proposed analyzer would allow detecting, identifying and removing anthrax laden letters in a mail-sorting machine prior to distribution. The … More

The overall objective of the proposed program is to develop a bed-side analyzer capable of providing rapid identification and quantification of chemotherapy drugs and metabolites in serum and urine. The analyzer would allow optimizing effectiveness and minimizing adverse side-effects associated… More

This Small Business Innovation Research (SBIR) Phase II Project will develop a novel microchip chemical analyzer that incorporates a new nanomaterial that performs both separation and detection of small quantities of chemicals and biochemicals. Phase I demonstrated feasibility by incorporating a… More

This Small Business Innovation Research (SBIR) Phase II Project will develop a novel microchip chemical analyzer that incorporates a new nanomaterial that performs both separation and detection of small quantities of chemicals and biochemicals. Phase I demonstrated feasibility by incorporating a… More

Rapid,

This Small Business Innovation Research Phase II project will develop two prototype anthrax detector systems designed to screen mail entering a postal facility and/or to identify and to stop distribution of anthrax containing mail as it passes through a sorter. These systems will be able to detect… More

This Small Business Innovation Research program will develop a novel surface-enhanced Raman (SER) sensor that will perform real-time chemical analysis of urine. It will provide key physiologic information to monitor astronaut health and indicate appropriate preventative treatment. The Phase I… More

The overall goal of this program (through Phase III) is to develop an astrobiology analyzer to measure chemical signatures of life in extraterrestrial settings. The analyzer will employ a lab-on-a-chip to extract biochemical signatures from soil or water samples and surface-enhanced Raman… More

The overall goal of this program (through Phase III) is to develop an analyzer that can be integrated into International Space Station (ISS) toilets to measure key chemicals in urine. The analyzer will employ a novel metal-doped sol-gel material to both separate these key chemicals from urine and… More

The overall goal of this program (through Phase III) is to develop an analyzer to measure chemical signatures of life in extraterrestrial settings. The analyzer will employ a lab-on-a-chip to extract biochemical signatures from soil or water samples and surface-enhanced Raman spectroscopy (SERS) to… More

This Small Business Innovation Research (SBIR) Phase I research project will develop Raman spectroscopy as a novel analytical tool to monitor and control chemistry in small-scale reactors (microliter to milliliter). Small scale reactors are being developed to: (1) create new chemical reaction… More

The overall goal of this proposed program (through Phase III) is to provide the EPA with a chemical sensor thatn can be multiplerxed into water distributon systems to provide early warning of poisoned water supples. This will be accomplished by developing surface-enhanced Raman (SER) sensors than… More

Modern agriculture depends on pesticides to curb infestations and increase crop yield and to produce the quantity and quality of food demanded by today's society. However, many pesticides kill insects by attack of the central nervous system, and use of excessive concentrations pose a threat to human… More

The overall goal of this proposed program (through Phase III) is to provide the municipal water authorities and the EPA with a chemical sensor that can be multiplexed into water distribution systems to provide early warning of poisoned water supplies. This will be accomplished by developing… More

The overall goal of this proposed program (through Phase III) is to build a hand-held Raman analyzer that can perform non-contact identification of chemicals in the field. This will be accomplished by modifying a commercially available FT-Raman analyzer to employ 976 or 1064 nm laser excitation. … More

This Small Business Innovation Research Phase I project develops assay chips that can detect, identify, and quantify the presence of Category A or B bioagents at the required sensitivity within 10 minutes. The assay chips will employ silver particles in a porous sol-gel to selectively extract and… More

The overall goal of this proposed program (through Phase III) is to build a hand-held Raman analyzer that can perform non-contact identification and hazard classification of chemicals in the field. This will be accomplished by building an exceptionally small interferometer, and producing a… More

The overall goal of this proposed program (through Phase III) is to develop a chip-scale assay that can detect, identify, and quantify the presence of Category A (or B) bioagents in water at the required sensitivity (e.g. 400 B. anthracis spores or 15 g of ricin per liter water) within 10 minutes. … More

This Small Business Innovation Research (SBIR) Phase II project will develop a prototype analyzer that can detect, identify, and quantify the presence of Category A (B and C) bioagents at the required specificity and sensitivity (e.g. in air 104 spores/m3, 100 organisms/m3 and 2-300 mg toxin/m3)… More

The overall goal of this proposed program (through Phase III) is to develop a chemical warfare agent analyzer capable of detecting vapor phase agents at 10-7g/m3 in less than 1 minute. This will be accomplished by developing a method to produce novel localized surface plasmon resonance (LSPR)… More

The overall goal of this proposed program (through Phase III) is to develop a chip-scale assay that can detect, identify, and quantify the presence of Category A (or B) bioagents in water at the required sensitivity (e.g. 8000 B. anthracis spores or 50µg of ricin per liter water) within 10 minutes.… More

The goal of this Phase II program is to bring the Marine Corps (RTA) Fuel Analyzer to a readiness level sufficient for production. This will accomplished by building three test units to establish temperature use range and validate fuel property analysis.

This Small Business Innovation Research Phase I project will demonstrate feasibility by developing a novel sampling system to detect 103-4 cfu/g Salmonella typhimurium in spinach within 2 hours. Foodborne diseases resulting from Campylobacter, Escherichia, Listeria, Salmonella, Shigella and Vibrio… More

DESCRIPTION (provided by applicant): The overall aim of this SBIR program is to develop a surface-enhanced Raman spectroscopy (SERS) based device for on-site analysis of drugs in saliva. This device will allow immediate assessment of both medicinal and illicit drug use by patients with… More