This Small Business Technology Transfer (STTR) Phase I research project aims to develop new probes for targeting specific cellular compartments. This will be achieved by producing a library of green fluorescent-tagged proteins using a high throughput insertion strategy. Availability of these… More
Award Year / Program / Phase:2008 / STTR / Phase I
Agency:HHS
Research Institution:N/A
Principal Investigator:
Award Amount:$210,092.00
RI Contact:N/A
Abstract:
DESCRIPTION (provided by applicant): A New Modular Tool Set for Live Imaging and Manipulating the Nervous System Project summary. The nervous system contains the most complex and heterogeneous set of cell types in the body. Modern approaches in imaging, an
d genetically encoded reporters based on… More
DESCRIPTION (provided by applicant): Project Summary/Abstract Drug discovery depends crucially upon reliable assays for biological activity. Live cell assays provide a rich environment for measuring biological activity. Coupled with genetically encodedfluorescent biosensors, live cell assays… More
This Small Business Innovation Research (SBIR) Phase I project will establish the feasibility of developing a genetically-encoded biosensor to monitor levels of cyclic adenosine monophosphate (cAMP), an important second messenger component of drug signaling pathways. Unlike existing FRET-based… More