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In vivo evaluation of a new ligand with picomolar affinity for the serotonin tran

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 1R43MH079568-01A1
Agency Tracking Number: MH079568
Amount: $500,000.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: PHS2007-2
Timeline
Solicitation Year: 2008
Award Year: 2008
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
MOLECULAR NEUROIMAGING, LLC 60 TEMPLE STREET, SUITE 8A
NEW HAVEN, CT 06510
United States
DUNS: 020285081
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 GILLES TAMAGNAN
 (203) 401-4309
 GTAMAGNAN@INDD.ORG
Business Contact
Phone: (203) 401-4351
Email: jmariotti@indd.org
Research Institution
N/A
Abstract

DESCRIPTION (provided by applicant): The goal of this research project is to validate in humans a new ligand with picomolar affinity for the serotonin transporter. It will permit quantitative measurement of serotonin transporter (5- HTT) sites in living br
ain by imaging with single photon emission tomography (SPECT). The serotonin transporter is known to play a critical role in several physiological and pathophysiological processes, including depression, anxiety, seasonal affective disorder, bulimia, and ps
ychosis, as demonstrated by post-mortem data, clinical efficacy of therapies affecting this target site, and imaging studies. A radiotracer that binds specifically to 5-HTT is of great utility in diagnosis, monitoring treatment, and research of these disor
ders. There is a need for better tracers that allow quantitation in areas of the brain with low 5-HTT densities such as the cortex.

* Information listed above is at the time of submission. *

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