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In vivo evaluation of a new ligand with picomolar affinity for the serotonin tran
Phone: (203) 401-4309
Email: GTAMAGNAN@INDD.ORG
Email: jmariotti@indd.org
DESCRIPTION (provided by applicant): The goal of this research project is to validate in humans a new ligand with picomolar affinity for the serotonin transporter. It will permit quantitative measurement of serotonin transporter (5- HTT) sites in living br
ain by imaging with single photon emission tomography (SPECT). The serotonin transporter is known to play a critical role in several physiological and pathophysiological processes, including depression, anxiety, seasonal affective disorder, bulimia, and ps
ychosis, as demonstrated by post-mortem data, clinical efficacy of therapies affecting this target site, and imaging studies. A radiotracer that binds specifically to 5-HTT is of great utility in diagnosis, monitoring treatment, and research of these disor
ders. There is a need for better tracers that allow quantitation in areas of the brain with low 5-HTT densities such as the cortex.
* Information listed above is at the time of submission. *