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COMPUTER MICROSCOPY AND NEUROINFORMATICS SYSTEM
Phone: () -
Email: JGLASER@MICROBRIGHTFIELD.COM
DESCRIPTION: We will develop a neuroinformatics system that will allow
neuroscientists to collect extremely large images of microscopic specimens at
the highest magnification of a light microscope, to store them in a web-enabled
database, and to share them with colleagues and students over the Internet and
intranets. Once collected, these extremely large images will be in effect,
"virtual slides." The virtual slides, composed of thousands of fields of view,
will enable researchers to view complete tissue specimens at any level of
magnification. Important information about the brain often requires examination
of a specimen at several different magnifications. For instance, low
magnification is required to identify large anatomical regions while higher
magnification is required to identify finer structure, such as individual
cells, dendrites, spines, etc. Our innovative system will provide new
opportunities for the neuroscience community to share research over the
Internet. In Phase II we expect to expand the system: to use illumination
techniques other than brightfield (e.g. fluorescence); to merge virtual slides
obtained from multi-illumination techniques into a multi-layer virtual slide;
and to combine graphic overlays with virtual slides to create high-resolution
atlases.
PROPOSED COMMERCIAL APPLICATION:
Internet system for archiving and comparing images for clinical pathology; commercial
web sites for education and research within an beyond the neuroscience area; a
service to create and maintain the virtual slides and database for a customer's web
site; and creation of large-scale images for text books and stereotaxic atlases.
* Information listed above is at the time of submission. *