This project will conduct research and development on the personal computer software package, neurolucida, which is intended for use in bioimaging and computer microscopy. itsmajor application is to light microscopy. it is also applicable to electron microscopy where it would facilitate serial… More

The applicant will develop a comprehensive software application that combines three dimensional (3-stereology, spatial point analysis, and mapping brain regions of unlimited size. The mathematical anprinciples underlying the methods are well established. The software will be Microsoft Windows(R)… More

DESCRIPTION: We will develop a neuroinformatics system that will allow neuroscientists to collect extremely large images of microscopic specimens at the highest magnification of a light microscope, to store them in a web-enabled database, and to share them with colleagues… More

This Small Business Innovation Research (SBIR) Phase I from MicoBrightField, Inc provides a plan for creating a bioinformatics system that will allow users to acquire images of complete microscopic specimens at the highest magnification of a light microscope, to store these very large images in a… More

DESCRIPTION (provided by applicant): We propose development of a commercial software product, AutoNeuron TM to perform automatic 3D neuron reconstruction. This software will run on a standard desktop PC with the Microsoft Windows(r) operating system and is performed on images acquired from specimen… More

DESCRIPTION (provided by applicant): We propose development of a commercial software product, AutoNeuron TM to perform automatic 3D neuron reconstruction. This software will run on a standard desktop PC with the Microsoft Windows(r) operating system and is performed on images acquired from specimen… More

DESCRIPTION (provided by applicant): The goal of this application is to develop a comprehensive system for the acquisition and quantitative analysis of focusable (3D) virtual slides. A 3D virtual slide is a complete digital representation of a tissue specimen imaged through a microscope,… More

DESCRIPTION (provided by applicant): Rigorous quantification methods of histological specimens have become a keystone in modern neuroscience such as investigations of neurogenesis, stem cell research, neurotransplantation, neurotoxicology, and the pathogen esis of neurodegenerative and… More

DESCRIPTION (provided by applicant): We propose the Sirius workstation, an innovative microscope system combining the capabilities of automated neuron reconstruction using guided image collection, cell electrophysiological recording, and cell filling in li ve tissue. Sirius will be the first… More

DESCRIPTION (provided by applicant): The soil nematode, Caenorhabditis elegans (C. elegans), is a promising model organism to assess the effects of potential developmental and neurological toxicants on multi-cellular organisms. However, to determine the po ssibility of using C. elegans as a… More

DESCRIPTION (provided by applicant): We propose the Orion workstation, an innovative, next generation microscope system that provides analysis tools for fully-automated quantitative change analysis in neurite outgrowth dynamics and neuronal precursor migra tion. The algorithms that will form the… More

DESCRIPTION (provided by applicant): We propose to develop NeuroAutomatica, an innovative, automated neuron reconstruction software platform that provides analysis tools for automated quantitative analysis of neuronal structure. The software will provide multi-scalar information about multiple… More

DESCRIPTION (provided by applicant): We propose a commercial product composed of a computerized microscope system that allows investigators to perform automated, quantitative analyses of locomotory and other complex behaviors of freely moving C. elegans ne matodes. Using the soil nematode, C.… More

DESCRIPTION (provided by applicant): We propose a commercial product composed of a computerized microscope system that allows investigators to perform automated cell counting and measuring using design-based stereology (DBS), as well as automated reconstruction of cytoarchitecture (ROC), on tissue… More

DESCRIPTION (provided by applicant): We propose the Radial Scanning Objective (RSO), an innovative microscope objective that permits simultaneous automated neuron reconstruction using guided image collection, cell electrophysiological recording, and cell loading in live tissue. The RSO device… More

DESCRIPTION (provided by applicant): This project aims at developing the Orion microscope system, a highly innovative combined software/hardware product, which will facilitate automated investigations of dynamics of migration of neuronal precursors and neurite outgrowth in vitro using time-lapse… More

DESCRIPTION (provided by applicant): Neuromorphologic analyses at the light microscopic level have significantly contributed to our understanding of the function and pathology of the brain. We propose to develop an integrated commercial product for providing automatic, immediate feedback about the… More

DESCRIPTION (provided by applicant): In this Lab to Marketplace proposal, we aim to develop the MBF SpineStudio software incorporating the innovative, laboratory-based NeuronStudio software created at the Mount Sinai School of Medicine. Our SpineStudio software will enable automated detection,… More