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PRODUCTION OF PYROGEN-FREE WATER IN HEMODIALYSIS UNITS

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 2R44DK056523-02
Agency Tracking Number: DK056523
Amount: $0.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Timeline
Solicitation Year: N/A
Award Year: 2002
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
LYNNTECH, INC. 7610 EASTMARK DR, STE 202
COLLEGE STATION, TX 77840
United States
DUNS: N/A
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 ANUNCIA GONZALEZMARTIN
 (979) 693-0017
 ANUNCIA.GONZALEX.MARTIN@LYNNTECH.COM
Business Contact
 G HITCHENS
Phone: (979) 693-0017
Email: LYNNTECH@LYNNTECH.COM
Research Institution
N/A
Abstract

DESCRIPTION (provided by applicant): Many reported risks and hazards in
hemodialysis are associated with water quality, including pyrogenic
contamination. The typical patient on dialysis is exposed to between 30 to 40
times the amount of water to which a member of the general population is
exposed. Thus, the quality of hemodialysis water is obviously very important.
Current practices in hemodialysis systems do not guarantee pyrogen-free water.
Several drawbacks exist in using available procedures to achieve pyrogen-free
water: (i) addition of chemicals, which have to be monitored and destroyed
before the water contacts the dialysis membrane. Otherwise, the chemicals may
come in contact with the patient about blood; (ii) formation of toxic
by-products from the reaction of pyrogens with the disinfectant; (iii) no
on-line means of providing pyrogen-free water (i.e., batch-mode operation), and
(iv) cost. This project concerns the development and evaluation of an
efficient, fast, and cost-effective photoreactor to supply pyrogen-free water
on-line in hemodialysis system. The disinfecting agents are short-lived
hydroxyl radicals, one of the strongest oxidants known, which are produced
in-situ, and consumed inside the photoreactor. During the Phase II project, an
automated prototype system will be developed and integrated into a hemodialysis
system. Technical and cost evaluations will be carried out to provide the
foundation for a commercial system.
PROPOSED COMMERCIAL APPLICATION:
Pyrogen-free water is required in all hemodialysis systems. In addition, this technology will find application in other areas of the medical industry: large quantities of pyrogen-free water are required for intravenous infusion fluids, fluids for injection and for irrigation in operating rooms. Also, other industries, such as the hydroponics industry need sterile water.

* Information listed above is at the time of submission. *

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