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LIFESENSORS, INC.

Company Information
Address
271 GREAT VALLEY PKWY
MALVERN, PA 19355-1308
United States


http://www.lifesensors.com

Information

UEI: ECPPNPPB5U31

# of Employees: 15


Ownership Information

HUBZone Owned: No

Socially and Economically Disadvantaged: No

Woman Owned: No



Award Charts




Award Listing

  1. Novel Approaches for Tau PROTAC Drug Discovery

    Amount: $1,254,536.00

    Novel Approaches for Tau PROTAC Drug Discovery Alzheimer’s disease (AD), frontotemporal dementia (FTD), progressive supranuclear palsy (PSP) are a group of neurodegenerative diseases characterized b ...

    SBIRPhase II2023Department of Health and Human Services National Institutes of Health
  2. Rational design of bifunctional protein degrader drugs

    Amount: $1,737,772.00

    Ubiquitin (Ub) tags regulate multiple properties and functions of proteins in cells. Proteasomal degradation of target proteins is a well-established means whereby the Ub proteasome system (UPS) contr ...

    SBIRPhase II2021Department of Health and Human Services National Institutes of Health
  3. Development of Non-conventional PROTACs

    Amount: $300,000.00

    Ubiquitin (Ub) signaling regulates not only proteasomal protein degradation, but also protein trafficking, receptor- mediated signal transduction, and control of mitophagy and autophagy. Ub conjugatin ...

    SBIRPhase I2020Department of Health and Human Services National Institutes of Health
  4. Novel Approaches for PROTAC Drug Discovery

    Amount: $397,101.00

    PROteolysis TArgeting Chimeras (PROTACs) is a new therapeutic class comprised of small molecules binding a target protein and a ubiquitin (Ub) E3 ligase, enabling selective target degradation. PROTACs ...

    SBIRPhase I2020Department of Health and Human Services National Institutes of Health
  5. Determining the signatures of pan-ubiquitylation in the immune proteome as highly sensitive and effective markers for neurodegenerative disease

    Amount: $224,828.00

    SUMMARYAlzheimerandapos s diseaseADis the most devastating age related disease due to its damage to cognitive and motor capacityheavily care dependent natureand lack of early diagnostics and effective ...

    SBIRPhase I2019Department of Health and Human Services National Institutes of Health
  6. Rational design of bifunctional protein degrader drugs

    Amount: $299,611.00

    Ubiquitin mediated signaling plays a central role in the control of protein degradationUbiquitin ligases synthesize polyubiquitin chains on target proteinswhich are then degraded by the proteasomeThe ...

    SBIRPhase I2019Department of Health and Human Services National Institutes of Health
  7. Ubiquitin Proteasome System and Molecular Signatures of Alzheimer's Disease

    Amount: $1,797,376.00

    Tools are needed to establish the etiology of Alzheimer’s disease (AD), whose signatures appear before the disease presents. Early in AD is ubiquitylation of misfolded proteins; those not degraded b ...

    SBIRPhase II2019Department of Health and Human Services National Institutes of Health
  8. Linkage-specific ubiquitylation patterns as highly sensitive markers for neurodegenerative disease

    Amount: $1,498,256.00

    While sensitive imaging tools to detectamyloid and tau proteins and other biomarkers for established Alzheimer s diseaseADand other neurodegenerative diseases are availablesimilar tools for detecting ...

    SBIRPhase II2018Department of Health and Human Services National Institutes of Health
  9. Development of chain selective polyubiquitin markers as early detectors of Parkinson's and Alzheimer's Disease

    Amount: $190,258.00

    Mammalian cells remove misfolded proteins by degradation mediated by the ubiquitin Ub proteasome pathway and autophagy The first step in the development of neuronal dysfunction or neuronal death is ...

    SBIRPhase I2017Department of Health and Human Services National Institutes of Health
  10. Linkage-specific ubiquitylation patterns as highly sensitive markers for neurodegenerative disease

    Amount: $224,662.00

    Linkage specific ubiquitylation patterns as highly sensitive markers for neurodegenerative disease Abstract Despite an intensive effort by the government pharmaceutical companies and academic gro ...

    SBIRPhase I2016Department of Health and Human Services National Institutes of Health
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