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Company Information:

Company Name: Li-cor Biosciences
City: Lincoln
State: NE
Zip+4: 68504-1357
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Website URL: N/A
Phone: (402) 467-3576

Award Totals:

Program/Phase Award Amount ($) Number of Awards
SBIR Phase I $1,507,151.00 16
SBIR Phase II $3,259,954.00 6

Award List:

DNA Sequencing with Infrared Flourescence Biomolecules

Award Year / Program / Phase: 1995 / SBIR / Phase I
Agency: HHS
Principal Investigator:
Award Amount: $97,750.00

DETECTING BIOMOLECULES WITH NEAR-INFRARED FLUORESCENCE

Award Year / Program / Phase: 1997 / SBIR / Phase I
Agency: HHS
Principal Investigator: Petersen, kerry l
Award Amount: $100,000.00
Abstract:
DESCRIPTION: (Adapted from the Applicant's Abstact): LI-COR has combined solid-state optical technology with infrared fluorescent dye chemistry to detect and quantify DNA products with extremely high sensitivity. The applicant proposes to extend LI-COR's near-infrared (NIR) fluorescence technology… More

DNA Sequencing with Infrared Flourescence Biomolecules

Award Year / Program / Phase: 1997 / SBIR / Phase II
Agency: HHS
Principal Investigator:
Award Amount: $513,284.00

Open Path Carbon Dioxide Sensor

Award Year / Program / Phase: 1998 / SBIR / Phase I
Agency: DOE
Principal Investigator: Dr. Jonathan M. Welles , Senior Applications Scientist
Award Amount: $75,000.00
Abstract:
50942-98-I Open Path Carbon Dioxide Sensor--LI-COR, Inc., 4421 Superior Street, Lincoln, NE 68504-1327; (402) 467-3576 Dr. Jonathan M. Welles, Principal Investigator Dr. Gregory L. Biggs, Business Official DOE Grant No. DE-FG03-98ER82607 Amount: $75,000 Long term measurements of the… More

SYNTHETIC APPROACH TO SINGLE MOLECULE DNA SEQUENCING

Award Year / Program / Phase: 1999 / SBIR / Phase I
Agency: HHS
Principal Investigator: John G. Williams
Award Amount: $117,000.00
Abstract:
Not Available The 21st century Navy will need complete awareness of the surface and subsurface situations across a wide area of interest, in spite of the constraints of reduced budgets and manning levels, and the need for closer collaboration with other forces. To meet these new challenges, the… More

N/A

Award Year / Program / Phase: 2000 / SBIR / Phase I
Agency: HHS
Principal Investigator: John G. Williams
Award Amount: $0.00

N/A

Award Year / Program / Phase: 2000 / SBIR / Phase II
Agency: HHS
Principal Investigator: John G. Williams
Award Amount: $370,000.00

N/A

Award Year / Program / Phase: 2000 / SBIR / Phase I
Agency: HHS
Principal Investigator: Amy R. Schutz
Award Amount: $0.00

N/A

Award Year / Program / Phase: 2000 / SBIR / Phase II
Agency: HHS
Principal Investigator: Amy R. Schutz
Award Amount: $454,500.00

DNA polymerase for single molecule DNA sequencing

Award Year / Program / Phase: 2001 / SBIR / Phase I
Agency: HHS
Principal Investigator: John G. Williams
Award Amount: $0.00
Abstract:
DESCRIPTION (provided by applicant): We are developing a new technology for single molecule DNA sequencing based on the incorporation of dNTPs labeled on the g-phosphate with fluorescent dyes. The label is cleaved from the nucleotide along with pyrophosphate when the nucleotide… More

DNA polymerase for single molecule DNA sequencing

Award Year / Program / Phase: 2001 / SBIR / Phase II
Agency: HHS
Principal Investigator: John G. Williams
Award Amount: $422,170.00
Abstract:
DESCRIPTION (provided by applicant): We are developing a new technology for single molecule DNA sequencing based on the incorporation of dNTPs labeled on the g-phosphate with fluorescent dyes. The label is cleaved from the nucleotide along with pyrophosphate when the nucleotide… More

DNA POLYMERASES FOR SINGLE MOLECULE DNA SEQUENCING

Award Year / Program / Phase: 2001 / SBIR / Phase I
Agency: HHS
Principal Investigator: John G. Williams
Award Amount: $100,000.00
Abstract:
APPLICANT'S DESCRIPTION: DNA polymerases with altered substrate specificity are needed to support a new approach to single molecule DNA sequencing. Single molecule methods can be applied to DNA isolated directly from a subject organism, eliminating the need to clone, map and sort DNA fragments prior… More

FOUR-COLOR MICROSCOPE FOR SINGLE-MOLECULE SEQUENCING

Award Year / Program / Phase: 2002 / SBIR / Phase I
Agency: HHS
Principal Investigator: Gregory R. Bashford
Award Amount: $149,888.00
Abstract:
We have been developing a system for real-time single molecule DNA sequencing. System components include novel "charge-switched" nucleotides, an adapted DNA polymerase, a method for isolating and handling single DNA molecules, a microfluidics controller and flowcell for sorting molecules by charge,… More

Single-Molecule Image Analysis for DNA Sequencing

Award Year / Program / Phase: 2003 / SBIR / Phase I
Agency: HHS
Principal Investigator: Patrick G. Humphrey
Award Amount: $117,150.00
Abstract:
DESCRIPTION (provided by applicant): We have been developing a system for real-time single molecule DNA sequencing. System components include novel "charge-switched" nucleotides, an adapted DNA polymerase, a method for isolating and handling single DNA molecules, a microfluidics flowcell for sorting… More

A Laser-based Instrument Platform for Measuring Methane and Other Trace Gases

Award Year / Program / Phase: 2005 / SBIR / Phase I
Agency: DOE
Principal Investigator: Liukang Xu, Dr.
Award Amount: $100,000.00
Abstract:
78618S Robust and reliable trace-gas analyzers (e.g., for isotopic carbon, methane, nitroxide, ammonia, etc.), suitable for long-term measurements, are not commercially available. Such analyzers are needed to achieve a better understanding of the global budget of these trace gases and to quantify… More

Electrokinetic Method For Single Molecule DNA Sequencing

Award Year / Program / Phase: 2005 / SBIR / Phase I
Agency: HHS
Principal Investigator: John G. Williams
Award Amount: $99,950.00
Abstract:
DESCRIPTION (provided by applicant): We propose a new approach to single-molecule DMA sequencing that can be done in a simple microtiter plate fitted with two electrodes. Over two-hundred different single DMA molecules would be sequenced simultaneously in a single well (maximum 10 nt/s per… More

Metal Enhancement for a Near-IR Fluorescence Scanner

Award Year / Program / Phase: 2005 / SBIR / Phase I
Agency: HHS
Principal Investigator: Jon P. Anderson
Award Amount: $200,413.00
Abstract:
DESCRIPTION (provided by applicant): Fluorescent molecules that are in close proximity to metallic surfaces, including silver and gold island films, produce increased fluorescence intensity along with increased photostability and decreased fluorescent lifetimes. These metal island films have been… More

A Laser-based Instrument Platform for Measuring Methane and Other Trace Gases

Award Year / Program / Phase: 2006 / SBIR / Phase II
Agency: DOE
Principal Investigator: Liukang Xu, Dr.
Award Amount: $750,000.00
Abstract:
Robust and reliable trace-gas analyzers (e.g., for isotopic carbon, methane, nitroxide, ammonia, etc.), suitable for long-term measurements, are not commercially available. Such analyzers are needed to achieve a better understanding of the global budget of these trace gases and to quantify their… More

Metal Enhancement for Near-IR Fluorescence Based Membrane Assays

Award Year / Program / Phase: 2007 / SBIR / Phase I
Agency: HHS
Principal Investigator: Jon P. Anderson
Award Amount: $100,000.00
Abstract:
DESCRIPTION (provided by applicant): Fluorescent molecules that are positioned in close proximity to silver nanoparticles produce increased fluorescence intensity along with increased photostability and decreased lifetimes. These silver structures have bee n studied in great detail for their ability… More

A Closed-Path Methane and Water Vapor Gas Analyzer

Award Year / Program / Phase: 2008 / SBIR / Phase I
Agency: DOE
Principal Investigator: Liukang Xu, Dr.
Award Amount: $100,000.00
Abstract:
A closed-path, methane and water vapor gas analyzer is required to support the widespread deployment that is needed to achieve a better understanding of the global methane budget and to quantify exchanges between the atmosphere and terrestrial biosphere. The analyzer must be robust, portable,… More

A Closed-Path Methane and Water Vapor Gas Analyzer

Award Year / Program / Phase: 2009 / SBIR / Phase II
Agency: DOE
Principal Investigator: Liukang Xu, Dr.
Award Amount: $750,000.00
Abstract:
A closed-path methane and water vapor gas analyzer ¿ which is robust, portable, has low power consumption consistent with solar powered applications, uses room-temperature lasers, and is suitable for long-term and remote field measurements ¿ is not commercially available. Yet, such an analyzer is… More

Low Cost Small Sample Volume High Precision Carbon Dioxide Analyzer

Award Year / Program / Phase: 2013 / SBIR / Phase I
Agency: DOE
Principal Investigator: Sergey Koulikov, Dr.
Award Amount: $150,000.00
Abstract:
LI-COR Biosciences proposes to develop a new sensor that measures the concentration of carbon dioxide in the atmosphere with precision of 1 part in 3000 within one minute, requires only small amounts of gas, operates unattended in the field for at least 6 months, costs less than $5000, and is… More