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Blue-Green Fiber Laser for Biomedical Applications

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: N/A
Agency Tracking Number: 1R43RR016406-01
Amount: $100,000.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Timeline
Solicitation Year: N/A
Award Year: 2001
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
2520 W 237TH ST
TORRANCE, CA 90505
United States
DUNS: N/A
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 ASHUTOSH SHARMA
 () -
Business Contact
Phone: (310) 530-7130
Email: RLIEBERMAN@INTOPSYS.COM
Research Institution
N/A
Abstract

DESCRIPTION (Provided by Applicant): Intelligent Optical Systems proposes to
develop a novel, low-cost, high-reliability, high-efficiency, dual-frequency
blue-green light source for automated DNA sequencers. This light source will
enable the creation of sequencers that are orders of magnitude more
energy-efficient, smaller, and cheaper, and -by producing illumination at more
nearly optimal wavelengths-will provide higher sequencing accuracy and greater
throughput, than the best current sequencers. It will have additional
applications in pathology and forensics laboratories, the dental industry, and
other biomedical applications. The new light source is a diode laser-pumped
dual-frequency fiber Bragg grating laser with an integrated dual-frequency
second harmonic generator. A double-clad optical fiber with an ytterbium-doped
core and two Bragg gratings will be pumped with a diode laser at 915 men. This
will simultaneously generate light at both 976 nm and 1060 nm with comparable
intensities. An intracavity non-linear crystal will generate second harmonics
at 488 nm and 530 nm. The resulting outputs will be very near optimum for
activation of the fluorescence of the marker compounds commonly used in DNA
sequencers and other genetics applications, enabling this new device to replace
the large and costly argon ion lasers now used.
PROPOSED COMMERCIAL APPLICATION:
This new light source will make it possible to develop novel, reliable, efficient, low cost,
portable instruments (including laser scanner, cytometers and DNA analyzer) that will
open new markets in pathology, forensics, and related areas. This new light source
will also be attractive to the dental industry for use in tooth whitening and bonding devices.

* Information listed above is at the time of submission. *

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