DESCRIPTION (provided by applicant): This project is designed to develop and demonstrate a facile, cost-effective, and broadly applicable thin-film coating technology for micro/nanoparticles in diagnostic, biotech, and therapeutic uses. This approach requires the preparation and use of amphiphilic… More

This Small Business Innovation Research (SBIR) Phase I project is designed to adapt a Giant MagnetoResistive (GMR) sensor device into a "spintronic" multianalyte biosensor. The potential value of biosensor technology is being recognized for a wide range of applications, from medical diagnostics to… More

DESCRIPTION (provided by applicant): This SBIR project is designed to demonstrate and develop an improved composition for nanofibers especially suitable for surface modification and biomolecule binding for cell culture and tissue engineering applications. A new trifunctional photoactivatible… More

DESCRIPTION (provided by applicant): The goal of this SBIR project is to develop drug-eluting biocompatible coatings for implantable orthopedic devices. The specific goal for the Phase I effort is the coating of orthopedic material for extended simultaneous delivery of three classes of antimicrobial… More

DESCRIPTION (provided by applicant): This SBIR Phase I project is designed to adapt a Giant Magneto-Resistive (GMR) sensor device into a "spintronic" multianalyte biosensor for pathogen detection. The potential value of biosensor technology is being recognized for a wide variety of applications,… More

DESCRIPTION (provided by applicant): This SBIR project is designed to develop a versatile and cost-effective coating technology for surfaces used in microarray devices, especially for proteomic and genomic analyses. The virtual well strip, slide or plate array will be developed with new… More

This Small Business Technology Transfer (STTR) Phase I project will demonstrate improved corrosion resistance of iron and aluminum alloys by coating the alloys with a durable superhydrophobic coating. The corrosion of metal has a major effect on the economy of industrial nations. The costs… More

DESCRIPTION (provided by applicant): This SBIR Phase I study is designed to develop and provide to the cell culture market, significantly improved surfaces for cell growth, differentiation control, and harvesting. The combination of two recently demonstrat ed improvements (thermally-responsive… More

This Small Business Innovation Research (SBIR) Phase I research project aims to develop super hydrophobic coatings for endotracheal tubes that can deliver antimicrobial drugs as well. The coatings and the process to coat the surfaces are proprietary, but the technology, if successful, may provide… More

DESCRIPTION (provided by applicant): This SBIR project is designed to develop a new non-viral carrier for target-specific delivery of small interfering RNA (siRNA). One of the major challenges in transforming siRNA from laboratory reagents to therapeutics is developing a target-specific delivery… More

This Small Business Technology Transfer (STTR) Phase II project will develop a superhydrophobic nanotextured coating that is highly water repelling and anti-corrosive. The coating will be applied to specific hearing aid surfaces (i.e., microphone ports, receiver, joints, battery, and case) to impart… More

DESCRIPTION (provided by applicant): This project is designed to develop novel catechol-functionalized polymers for medical device coatings with increased lubricity. Catechols have been shown to be key components in the adhesive proteins that mussels secre te to attach to underwater surfaces. The… More

DESCRIPTION (provided by applicant): This SBIR project is designed to develop thermo-responsive nanofibers as microcarriers for cell culture. Nanofiber surfaces provide a more in vivo like growth surface for mammalian cell growth and function. The use of t hermo-responsive polymer allows the cells… More

DESCRIPTION (provided by applicant): Project Summary This Phase I SBIR project is designed to develop new zwitterionic graft methodology for orthopedic surfaces with enhanced durability. As Americans live longer and more active lives, total joint replaceme nt is becoming more common. Current… More

DESCRIPTION (provided by applicant): This Phase I project is to evaluate a series of novel drug combinations to prevent and treat wound infections. Wounds have certain characteristics that promote the development of infections: the presence of devitalized tissue, foreign bodies, clots, fluid… More

DESCRIPTION (provided by applicant): This SBIR project is designed to develop miniaturized cell-based biosensors for low cost, portability and enhanced shelf life by extending the viability of the cultured mammalian cells. We will demonstrate the benefit of our current technology by creating… More

DESCRIPTION (provided by applicant): Neural Tract-tracing Nucleic Acid Carriers Existing transfection reagents perform very poorly in mature neurons in vitro, and are not suitable for in vivo use. This Phase I project will test the performance of a novelnucleic acid carrier under development at… More

DESCRIPTION (provided by applicant): This project is designed to develop novel catechol-functionalized polymers for medical device coatings with increased lubricity and biocompatibility. Catechols have been shown to be key components in the adhesive proteins that mussels secrete to attach to… More

DESCRIPTION (provided by applicant): This Small Business Innovation Research Phase I project is designed to develop new zwitterionic click methodology for orthopedic surfaces with enhanced durability. As Americans live longer and more actives lives, totaljoint replacement is becoming more common.… More