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ANTI-CD4 ANTIBODY AS A THERAPEUTIC AND PREVENTIVE HIV VACCINE

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 13622
Amount: $50,000.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Timeline
Solicitation Year: N/A
Award Year: 1990
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
11099 N Torrey Pines Rd #160
La Jolla, CA 92037
United States
DUNS: N/A
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Chang-yuil Kang
 (619) 458-0600
Business Contact
Phone: () -
Research Institution
N/A
Abstract

ATTEMPTS TO MAKE A PRACTICAL HIV VACCINE HAVE SO FAR BEEN UNSUCCESSFUL. THIS RESEARCH WILL USE AN ANTI-HIV RECEPTOR (CD4) ANTIBODY AS AN HIV VACCINE TO CIRCUMVENT THE CURRENT PROBLEMS OF HIV VACCINE TRIALS. THE APPROACH IS BASED UPON THE ASSUMPTION THAT CERTAIN ANTI-CD4 ANTIBODIES CAN STRUCTURALLY MIMIC THE NEUTRALIZING EPITOPE OF GP120 AND ELICIT NEUTRALIZING ANTI-GP120 ANTIBODIES. A PANEL OF MURINE ANTI-CD4 MONOCLONAL ANTIBODIES (MABS) WILL BE GENERATED AND CHARACTERIZED IN VITRO TO IDENTIFY CANDIDATES FOR GP120-MIMICKING ANTIBODIES BY EPITOPE MAPPING AND IN VITRO VIRUS NEUTRALIZATION ASSAYS. BASED UPON IN VITRO CHARACTERIZATIONS, ANTI-CD4 MABS WILL BE SELECTED AND EVALUATED IN VIVO TO IDENTIFY THEIR POTENTIAL UTILITY IN ELICITING NEUTRALIZING ANTI-GP120 ANTIBODIES AGAINST VARIOUS HIV ISOLATES. FOR THIS, RABBITS AND RATS WILL BE IMMUNIZED WITH ANTI-CD4 MABS, AND THE SERA WILL BE EVALUATED FOR NEUTRALIZING ANTI-GP120 ANTIBODIES BY MEASUREMENT OF ANTI-GP120 TITER IN ELISA AND VIRUS NEUTRALIZATION ASSAYS USING VARIOUS HIV ISOLATES. PHASE II RESEARCH WILL FURTHER EVALUATE THE EFFECT OF ANTI-CD4 MABS AS AN HIV VACCINE IN PRIMATES. AT THAT TIME, PROTECTION EXPERIMENTS AGAINST VIRAL INFECTION WILL BE PERFORMED.

* Information listed above is at the time of submission. *

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