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MONOCLONAL ANTIBODY ANTI-IDIOTYPE TUMOR VACCINES

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 3056
Amount: $455,000.00
Phase: Phase II
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Timeline
Solicitation Year: N/A
Award Year: 1988
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
11211 Sorrento Valley Rd Ste H
San Diego, CA 92121
United States
DUNS: N/A
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Robert E. Sobol
 Principal Investigator
 (619) 458-0600
Business Contact
Phone: () -
Research Institution
N/A
Abstract

THE OBJECTIVE OF THIS APPLICATION IS TO DEVELOP MONOCLONAL ANTIBODY (MOAB) ANTI-IDIOTYPE (ANTI-ID) TUMOR VACCINES FOR THE TREATMENT AND PREVENTION OF CANCER. THE SPECIFIC AIMS OF THE PHASE I PROPOSAL ARE TO DEFINE THE GENERAL PRINCIPLES FOR MAXIMIZING THE IN VIVO EFFICACY OF MOAB ANTI-ID TUMOR VACCINE PREPARATIONS. THIS WILL BE ACCOMPLISHED THROUGH A SYSTEMATIC COMPARISON OF ANTI-ID VACCINES REPRESENTING DIFFERENT TYPES OF TUMOR ASSOCIATED ANTIGENS (TAAS) IN A SOLID TUMOR ANIMAL MODEL. THESE PHASE I STUDIES WILL IDENTIFY THE CRITICAL VARIABLES AFFECTING THE THERAPEUTIC EFFICACY OF ANTI-ID TUMOR VACCINE PREPARATIONS. THE CONCLUSIONS DRAWN FROM THE PHASE I INVESTIGATIONS WILL OPTIMIZE THE DEVELOPMENT OF ANTI-ID TUMOR VACCINES FOR EVALUATION IN HUMAN CANCER PATIENTS IN PHASE II. IN CONTRAST TO CONVENTIONALLY PURIFIED TAA VACCINES, MOAB ANTI-ID PREPARATIONS CAN BE READILY PRODUCED IN LARGE QUANTITIES AND, UNLIKE RECOMBINANT DNA VACCINES, ANTI-ID VACCINES MAY BE EMPLOYED TO GENERATE IMMUNE RESPONSES AGAINST A WIDER VARIETY OF TAA DETERMINANTS, INCLUDING CARBOHYDRATE AND LIPID MOIETIES. THE RESULTS OF THE PHASE I AND II STUDIES, COMBINED WITH THE INHERENT ADVANTAGES OF ANTI-ID PREPARATIONS, MAY LEAD TO THE DEVELOPMENT OF NOVEL TUMOR VACCINE PRODUCTS USEFUL IN THE THERAPY OF HUMAN CANCERS.

* Information listed above is at the time of submission. *

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