FLOW CYTOMETRY-IMPROVING COST-EFFECTIVENESS

Award Information

Agency: Department of Health and Human Services

Branch: N/A

Contract: N/A

Agency Tracking Number: 5317

Amount: $485,000.00

Phase: Phase II

Program: SBIR

Solicitation Topic Code: N/A

Solicitation Number: N/A

Timeline

Solicitation Year: N/A

Award Year: 1988

Award Start Date (Proposal Award Date): N/A

Award End Date (Contract End Date): N/A

Small Business Information

HOWARD M. SHAPIRO, MD, P.C.

283 Highland Avenue

West Newton, MA 02165

United States

DUNS: N/A

HUBZone Owned: No

Woman Owned: No

Socially and Economically Disadvantaged: No

Principal Investigator

Name: Howard M Shapiro
Title: Principal Investigator
Phone: (617) 965-6044

Business Contact

Phone: () -

Research Institution

N/A

Abstract

FLOW CYTOMETRY IS USED FOR THE COUNTING, SIZING AND BIO- CHEMICAL CHARACTERIZATION OF SINGLE CELLS AND HAS BECOME INCREASINGLY IMPORTANT IN CELL BIOLOGY IN GENERAL AND IN STUDIES OF CELLULAR IMMUNITY AND CANCER IN PARTICULAR. THE COMPLEXITY AND COST OF THE MOST MODERN APPARATUS HAVE RESTRICTED THE RANGE OF EXPERIMENTAL AND CLINICAL APPLICA- TIONS OF THE TECHNIQUE. A NEW INSTRUMENT DESIGN THAT EMPLOYS OPTICAL WAVEGUIDES IN PLACE OF LENSES FOR ILLUMINA- TION AND COLLECTION AND UTILIZES LOW-POWER LASER LIGHT SOURCES WILL BE COMPARED WITH EXISTING APPARATUS IN ANALYSESOF DNA AND RNA CONTENT AND ANTIGEN EXPRESSION IN CULTURED EUKARYOTIC CELLS. NEW FLUORESCENT STAINS AND LIGHT SOURCES WILL BE EXAMINED FOR POSSIBLE ADVANTAGES FOR SUCH ANALYSES. LOW-POWER HELIUM-CADMIUM LASER SOURCES WILL BE EVALUATED FORBIVARIATE FLOW CYTOMETRIC ANALYSIS OF ISOLATED CHROMOSOMES.

* Information listed above is at the time of submission. *

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FLOW CYTOMETRY-IMPROVING COST-EFFECTIVENESS