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PALYTOXIN PRODRUG ACTIVATION BY ANTIBODY-LINKED ENZYME
Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 16417
Amount:
$459,212.00
Phase:
Phase II
Program:
SBIR
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Timeline
Solicitation Year:
N/A
Award Year:
1992
Award Start Date (Proposal Award Date):
N/A
Award End Date (Contract End Date):
N/A
Small Business Information
99-193 Aiea Heights Drive
Aiea, HI
96701
United States
DUNS:
N/A
HUBZone Owned:
No
Woman Owned:
No
Socially and Economically Disadvantaged:
No
Principal Investigator
Name: Bignami, Gary S
Title: Principal Investigator
Phone: (808) 486-5397
Title: Principal Investigator
Phone: (808) 486-5397
Business Contact
Name: 1 R43 CA54652-01
Phone: () -
Phone: () -
Research Institution
N/A
Abstract
PALYTOXIN IS AN EXTREMELY CYTOTOXIC LOW MOLECULAR WEIGHT NATURAL PRODUCT ISOLATED FROM SOFT CORALS OF THE GENUS, PALYTHOA. N-ACYLATED DERIVATIVES OF PALYTOXIN HAVE BEEN REPORTED TO BE UP TO 100-FOLD LESS CYTOTOXIC THAN THE UNMODIFIED TOXIN. PALYTOXIN N-ACYL DERIVATIVES WHICH CAN BE CONVERTED TO THE NATIVE TOXIN BY ANTITUMOR MONOCLONAL ANTIBODY- ENZYME CONJUGATES WILL BE PREPARED AND TESTED FOR ANTIGEN-SELECTIVE CYTOTOXICITY AGAINST CELLS IN CULTURE.
* Information listed above is at the time of submission. *