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PRODUCTION OF DENQUE 2 ENVELOP PROTEIN IN THE YEAST SACCHAROMYCES CEREVISIAE

Award Information
Agency: Department of Defense
Branch: Army
Contract: N/A
Agency Tracking Number: 9775
Amount: $571,526.00
Phase: Phase II
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Timeline
Solicitation Year: N/A
Award Year: 1991
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
99-193 Aiea Heights Dr
Aiea, HI 96701
United States
DUNS: N/A
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Dr John M Ivy
 (808) 486-5380
Business Contact
Phone: () -
Research Institution
N/A
Abstract

THE FOUR SEROTYPES OF DENGUE VIRUSES ARE A LEADING CAUSE OF MORBIDITY THROUGHOUT THE TROPICS AND SUBTROPICS. FOR USE IN DIAGNOSTICS AND IN SUBUNIT VACCINES AGAINST DENGUE, A RELIABLE AND INEXPENSIVE SOURCE OF DENGUE ANTIGENS IS REQUIRED. FOR THESE PURPOSES, EXPRESSION OF RECOMBINANT ANTIGENS IN MICROORGANISMS IS BEST SUITED. WE PROPOSE TO USE THE YEAST SACCHAROMYCES CEREVISIAE TO PRODUCE THE DENGUE 2 VIRUS ENVELOPE GLYCOPROTEIN. THE SEQUENCES ENCODING THE ENVELOP PROTEIN WILL BE PLACED UNDER THE TRANSCRIPTIONAL CONTROL OF BOTH A CONSTITUTIVE AND A REGULATED PROMOTER, WITH AND WITHOUT SECRETION SIGNAL PEPTIDES. RELATIVE AMOUNTS OF ANTIGENIC MATERIAL WILL BE DETERMINED FOR EACH SYSTEM.

* Information listed above is at the time of submission. *

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