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GLIAL ANTIPROLIFERATIVE FACTOR AS A TUMOROSTATIC AGENT

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 18993
Amount: $50,000.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Timeline
Solicitation Year: N/A
Award Year: 1992
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
23420 Commerce Park Road
Beachwood, OH 44122
United States
DUNS: N/A
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Dianne Lorton
 (216) 831-3200
Business Contact
Phone: () -
Research Institution
N/A
Abstract

MALIGNANT GLIOMAS ARE THE MOST COMMONLY OCCURRING CEREBRAL NEOPLASMS IN HUMANS. THE INCIDENCE OF PRIMARY BRAIN TUMORS IS 16,000 CASES ANNUALLY, WITH MALIGNANT GLIOMAS (GLIOBLASTOMA MULTIFORMS) COMPRISING 20-40% OF THESE CASES. DESPITE CONCENTRATED RESEARCH EFFORTS, THE OUTLOOK FOR GLIOMA PATIENTS REMAINS GRIM. APPROXIMATELY 90% OF ALL GLIOMA PATIENTS DIE WITHIN TWO YEARS OF DIAGNOSIS. THE RESEARCH EXAMINES THE USE OF GLIAL ANTIPROLIFERATIVE FACTORS DERIVED FROM SCHWANN CELLS (SC) OR SYNTHESIZED BY SC PROTEASES FOR TREATMENT OF MALIGNANT GLIOMAS. STUDIES TO DETERMINE THE MECHANISMS UNDERLYING THE CESSATION OF SC PROLIFERATION IN VITRO HAVE DEMONSTRATED THAT SC CONDITIONED MEDIUM (CM) INHIBITS GLIA CELL PROLIFERATION IN VITRO. THIS ANTIPROLIFERATIVE ACTIVITY RESULTS FOLLOWING PRODUCTION OF A 55 KD PROTEIN BY SCS. THIS PROTEIN IS A ZN++ METALLOPROTEASE WHICH ACTS ON FIBRONECTIN TO PRODUCE 29 KD HEPARIN-BINDING FIBRONECTIN GRAGMENTS, WHICH ALSO INHIBIT IN VITRO PRIMARY GLIAL CELL AND GLIOMA PROLIFERATION. THE EXPERIMENTS WILL EVALUATE THE ABILITY OF THE 29 KD PROTEIN, TERMED GLIAL ANTIPROLIFERATIVE PROTEIN (GAP), TO INHIBIT GLIAL TUMOR CELL PROLIFERATION AND GROWTH IN VITRO AND INVIVO. IN PHASE I1, DRUG FORMULATION AND THE USE OF GAP IN COMBINATION WITH RESECTION, RADIATION, AND CHEMOTHERAPY FOR TREATING GLIOBLASTOMAS WILL BE EXAMINED.

* Information listed above is at the time of submission. *

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