Survival rates of human platelets cryopreserved using current methods are very low (10%). This is largely due to a lack of knowledge regarding the fundamental cryobiology of this cell type. Because of this limitation, most blood banks maintain platelets in non-frozen solutions. Using this… More

Not Available A program is proposed to demonstrates a low cost material, design and manufacturing method for the elastomer-encapsulated, laterally-confined ceramic armor component to limit lateral damage, to increase ballistic efficiency, and to allow multiple impacts without ballistic performance… More

Not Available This proposal explores a variation of the Laser Induced Incandescence (LII) technique, and its integration with a multi-wavelength laser scattering/extinction technique, for measuring the soot concentration, soot primary size, and soot size distribution i

DESCRIPTION (provided by applicant): With increasing effort directed toward purification and/or in vitro expansion of hematopoietic progenitor cells (HPCs) for either fundamental research or clinical applications, there is an associated, increased need for the development of improved, efficient… More

DESCRIPTION (provided by applicant): With increasing effort directed toward purification and/or in vitro expansion of hematopoietic progenitor cells (HPCs) for either fundamental research or clinical applications, there is an associated, increased need for the development of improved, efficient… More

DESCRIPTION (provided by applicant): The present proposal relates to a method of inducing ice formation (e.g. ice nucleation or "seeding") in aqueous solutions surrounding cells and tissues during low temperature preservation (cryopreservation). Typically, seeding is performed by touching the sample… More

DESCRIPTION (provided by applicant): High dose chemotherapy followed by peripheral blood hematopoietic stem cell (PBSC) transplantation is frequently used for treating various hematologic malignancies. To facilitate this process, autologous PBSC are typically collected, cryopreserved and stored for… More

DESCRIPTION (provided by applicant): High dose chemotherapy followed by peripheral blood hematopoietic stem cell (PBSC) transplantation is frequently used for treating various hematologic malignancies. To facilitate this process, autologous PBSC are typica lly collected, cryopreserved and stored for… More

DESCRIPTION (provided by applicant): The overall goal of this application is to develop an understanding of the collection, processing and cryobiological characteristics of stem/progenitor cells recovered from extracted teeth with the ultimate culmination of these data to allow for a cryobank of… More

DESCRIPTION (provided by applicant): Genetically engineered mouse (GEM) and rat (GER) lines are excellent animal models for many important human diseases (Cox, 2003; Green and Hudson, 2005). However, maintenance of these lines by standard breeding techniqu es is producing unsustainable pressure on… More

DESCRIPTION (provided by applicant): The overall goal of this proposal is to build on our understanding of the collection, processing and cryobiological characteristics of stem/progenitor cells recovered from extracted teeth with the ultimate culmination of these data to develop a cryobank of… More

DESCRIPTION (provided by applicant): Therapeutic Angiogenesis by Universal Donor Endometrial Regenerative Cells (ERC) Abstract The proposed study seeks to develop a practical, off the shelf, universal donor, cell therapy for an advanced form of peripheral artery disease termed critical limb… More

DESCRIPTION (provided by applicant): The overall goal of this proposal is to design and develop a type of cryopreservation media and an easy-to-use cooling device that allow the long-term storage and safe shipment of animal model germplasm (embryos and spermatozoa) and embryonic stem cells (ESCs) at… More