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Camouflaged liposome construct for efficient drug delivery across the blood-brain barrier

Award Information
Agency: Department of Defense
Branch: Office for Chemical and Biological Defense
Contract: W81XWH-08-C-0085
Agency Tracking Number: C081-107-0077
Amount: $69,979.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: CBD08-107
Solicitation Number: 2008.1
Timeline
Solicitation Year: 2008
Award Year: 2008
Award Start Date (Proposal Award Date): 2008-05-08
Award End Date (Contract End Date): 2008-11-07
Small Business Information
1 Riverside Circle Suite 400
Roanoke, VA 24016
United States
DUNS: 627132913
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Krista Niece
 Principal Investigator
 (540) 769-8400
 submissions305@lunainnovations.com
Business Contact
 Laura Rasnick
Title: Contracts Administrator
Phone: (540) 769-8431
Email: submissions305@lunainnovations.com
Research Institution
N/A
Abstract

A major obstacle to non-invasive treatment of brain injury and disease is the blood-brain barrier (BBB), which prevents many intravenously injected therapeutics from being taken into the brain. In this program, Luna Innovations and Virginia Tech propose to develop a novel liposome-based delivery system capable of delivering any of a variety of neuroprotective agents of use against organophosphate-based nerve agents. This novel system combines a recently developed “Trojan horse” peptide capable of ferrying the construct across the BBB with liposome technology previously developed at Luna that can be adapted to achieve drug delivery over a specified time frame. The proposed system also has neural specificity, targeting the tissues that are most affected by nerve agents. During Phase I, the Luna team will synthesize and assemble the system components, demonstrate encapsulation of assorted neuroprotective agents, and perform preliminary in vivo and in vitro testing of system efficacy.

* Information listed above is at the time of submission. *

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