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Ultrasonic Derivative Measurements of Bone Strain During Exercise

Award Information
Agency: National Aeronautics and Space Administration
Branch: N/A
Contract: NNC05CA44C
Agency Tracking Number: 041210
Amount: $69,955.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: B3.05
Solicitation Number: N/A
Timeline
Solicitation Year: 2004
Award Year: 2005
Award Start Date (Proposal Award Date): 2005-01-19
Award End Date (Contract End Date): 2005-07-25
Small Business Information
2851 Commerce Street
Blacksburg, VA 24060-6657
United States
DUNS: 627132913
HUBZone Owned: Yes
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 John Lynch
 Principal Investigator
 (757) 224-0687
 keena@lunainnovations.com
Business Contact
 Wendy Vogt
Title: Director of Contracts
Phone: (540) 552-5128
Email: vogtw@lunainnovations.com
Research Institution
N/A
Abstract

Luna Innovations, Inc., in collaboration with the SUNY Stony Brook, proposes to extend ultrasonic pulsed phase locked loop (PPLL) derivative measurements to the noninvasive assessment of bone strain during exercise. The PPLL is a high-resolution ultrasonic spectrometer that measures changes in natural velocity with parts in ten million accuracy. With this resolution, the PPLL can be used to measure a material's nonlinear elastic constants, which are related to changes in the speed of sound as it is loaded. Nonlinear elastic constants are more closely linked to bone strength than traditional absolute measurements of the speed of sound, thus providing an important new capability for bone health assessment.

This technology has been demonstrated on a number of engineered materials, including fasteners, heat-treated aluminum, heat-treated steel, composite materials, railroad rails, and adhesive bonds. In Phase ILuna's PPLL technology will be tested on bone ex vivo at Stony Brook's Biomedical Engineering Department to develop a strong physics-based model of how natural velocity changes as a bone sample is loaded. This research will lay the groundwork for Phase II, in which Luna's PPLL technology will be combined with Stony Brook's scanning confocal acoustic diagnostic (SCAD) technology for in vivo studies.

* Information listed above is at the time of submission. *

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