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Company Information:

Company Name: Parabon NanoLabs, Inc.
City: Reston
State: VA
Zip+4: 20190-5203
Woman-Owned: No
Minority-Owned: No
HUBZone-Owned: No
Phone: N/A

Award Totals:

Program/Phase Award Amount ($) Number of Awards
SBIR Phase I $574,766.00 4
SBIR Phase II $3,249,888.00 4
STTR Phase I $200,000.00 2
STTR Phase II $1,215,948.00 2

Award List:

SBIR Phase II:Nano-scale Engineering via Grid-scale Computing: Designing, Optimizing and Manufacturing Cancer Therapeutics

Award Year / Program / Phase: 2010 / SBIR / Phase II
Agency: NSF
Principal Investigator: Steven L. Armentrout
Award Amount: $500,000.00
Abstract:
This Small Business Innovation Research (SBIR) Phase II project will advance the development of new drug compounds for the treatment of glioma, which have been designed and constructed with an innovative combination of grid-powered, computer-aided design (CAD) software and DNA nano-fabrication… More

Mixed-Ligand Targeting of a Nano-Pharmaceutical Against GBM Stem Cells

Award Year / Program / Phase: 2011 / SBIR / Phase I
Agency: HHS
Principal Investigator: Steven L. Armentrout – 703-689-9689
Award Amount: $174,766.00
Abstract:
DESCRIPTION (provided by applicant): In this Phase I SBIR project, Parabon NanoLabs, Inc. (PNL) will produce a novel, nano- pharmaceutical compound that preferentially selects and destroys brain tumor stem cells (BTSCs) to aid the treatment of glioblastomamultiforme (GBM), one of the most lethal… More

Origami Antibodies for Threat Sensing

Award Year / Program / Phase: 2011 / STTR / Phase I
Agency / Branch: DOD / ARMY
Research Institution: Marshall University
Principal Investigator: Michael Norton, Professor – (304) 696-6627
Award Amount: $100,000.00
RI Contact: John M. PhD
Abstract:
Beginning from an advanced stage of development, this Phase I STTR project will produce designs and prototypes for a ricin-specific artificial antibody constructed using DNA origami. These novel constructs will provide both a capture function (mimicking the properties of an antibody) and intrinsic… More

Design Software for DNA-Based Sensing Nano-Architectures

Award Year / Program / Phase: 2011 / STTR / Phase I
Agency / Branch: DOD / OSD
Research Institution: Marshall University Research Corp
Principal Investigator: Steven Armentrout, President – (703) 689-9689
Award Amount: $100,000.00
RI Contact: Janice Morgan
Abstract:
Beginning from an advanced stage of development, this Phase I SBIR project will produce design automation software for creating DNA nanostructures for a wide variety of applications, remedying a deficit that has stymied advancement in this promising field. Building atop an established grid… More

SNAPSHOT: A System for Predicting Human Physical Traits from Sample DNA

Award Year / Program / Phase: 2011 / SBIR / Phase I
Agency: DOD
Principal Investigator: Steven Armentrout, President – (703) 689-9689
Award Amount: $100,000.00
Abstract:
OBJECTIVE: Develop a Forensic DNA Analysis Kit for Genetic Intelligence that can be used on unknown human DNA samples collected from the battlefield to provide information about the individual who deposited the sample, such as potential ethnicity, height, eye color, hair color, age, sex, and/or… More

A Nano-pharmaceutical Platform for Creating Artificial Vaccines

Award Year / Program / Phase: 2011 / SBIR / Phase I
Agency: DOD
Principal Investigator: Steven Armentrout, CEO – (703) 689-9689
Award Amount: $150,000.00
Abstract:
In this project, Parabon NanoLabs (PNL) will demonstrate the feasibility of extending its Essemblix(tm) Drug Development Platform, a combination of computer-aided design (CAD) software and DNA nano-fabrication technology, to produce Essemblix-V, a platform for creating artificial vaccines from a… More

Design Software for DNA-Based Sensing Nano-Architectures

Award Year / Program / Phase: 2012 / STTR / Phase II
Agency / Branch: DOD / OSD
Research Institution: Duke University
Principal Investigator: Steven Armentrout, CEO – (703) 689-9689
Award Amount: $750,000.00
RI Contact: Keith Hurka-Owen
Abstract:
Building on an existing grid computing platform and DNA origami design automation software that leverages such, this Phase II STTR project will produce a CAD (computer-aided design) application for designing DNA nanostructures for a variety of applications. The application, called inSequio,… More

Design Automation Software for Biomimetic Surface Presentation with DNA Origami

Award Year / Program / Phase: 2012 / SBIR / Phase I
Agency / Branch: DOD / CBD
Principal Investigator: Steven Armentrout, President&CEO – (703) 689-9689
Award Amount: $150,000.00
Abstract:
A development program is proposed for a design automation software package that enables the generation of complex surfaces, with user defined or automated definition of point charge and hydrophobic/hydrophilic properties, using DNA origami as a presentation substrate. Building upon existing… More

SNAPSHOT: A System for Predicting Human Physical Traits from Sample DNA

Award Year / Program / Phase: 2012 / SBIR / Phase II
Agency: DOD
Principal Investigator: Steven Armentrout, CEO – (703) 689-9689
Award Amount: $1,000,000.00
Abstract:
This SBIR Phase II project will produce a working prototype of a DNA processing system that will provide the U.S. Department of Defense with a revolutionary new forensics capability, namely, the ability to predict from a human DNA sample the physical traits of its source. The system, code-named… More

Origami Antibodies for Threat Sensing

Award Year / Program / Phase: 2013 / STTR / Phase II
Agency / Branch: DOD / ARMY
Research Institution: Marshall University
Principal Investigator: Michael Norton, Professor – (304) 696-6627
Award Amount: $465,948.00
RI Contact: Janice Morgan
Abstract:
Beginning from an advanced stage of development, this Phase II STTR project will produce designs and prototypes for a ricin-specific artificial antibody constructed using DNA origami. These novel constructs will provide both a capture function (mimicking the properties of an antibody) and intrinsic… More

A Nano-pharmaceutical Platform for Creating Artificial Vaccines

Award Year / Program / Phase: 2013 / SBIR / Phase II
Agency: DOD
Principal Investigator: Steven Armentrout, CEO – (703) 689-9689
Award Amount: $749,918.00
Abstract:
In this project, Parabon NanoLabs will employ its Essemblix(tm) Drug Development Platform, a combination of computer-aided design (CAD) software and DNA nano-fabrication technology, to produce artificial vaccines against the biothreat agent ricin on DNA origami decorated first with natural epitopes… More

Design Automation Software for Biomimetic Surface Presentation with DNA Origami

Award Year / Program / Phase: 2014 / SBIR / Phase II
Agency / Branch: DOD / CBD
Principal Investigator: Steven Armentrout, Co-Founder&CEO – (703) 689-9689
Award Amount: $999,970.00
Abstract:
A development program is proposed for a design automation software package that enables the generation of complex surfaces, with user defined or automated definition of point charge and hydrophobic/hydrophilic properties, using DNA origami as a presentation substrate. Building upon Parabon"s… More