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Rapid, Bedside, Liquification of Solid Drugs

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 2R44GM066436-02A1
Agency Tracking Number: GM066436
Amount: $992,262.00
Phase: Phase II
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: PHS2005-2
Timeline
Solicitation Year: 2005
Award Year: 2005
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
Engineering Acoustics, Inc. 933 Lewis Dr, Ste C
Winter Park, FL 32789
United States
DUNS: N/A
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 BRUCE MORTIMER
 (407) 645-5444
 BMORT@EAIINFO.COM
Business Contact
 GARY ZETS
Phone: (407) 645-5444
Email: ZETS@EAIINFO.COM
Research Institution
N/A
Abstract

DESCRIPTION (provided by applicant): An estimated 3.75 billion drug administrations were made to patients in United States hospitals in 1998, of which approximately 10% received their medications as liquids through an enteral feeding tube (EFT). This number is growing. Despite a vast drug pharmacopoeia, and sophisticated medication distribution systems, the availability of liquid medications is limited. Less than 28% of oral drugs available in the United States are commercially available as liquids, and there are significant gaps in several important therapeutic categories. Increasing penetration of point-of-care automated dispensing in institutional healthcare much more readily supports solid drug distribution, putting additional logistical pressure on liquid drug distribution. Thus institutional caregivers still must "liquefy" capsules and tablets at the bedside for over 55% of the liquid medication needs of their patients - millions of doses - by "bash and smash" techniques. This extemporaneous compounding of liquid medications has significant problems impacting caregiver efficiency, enteral tube failure, and safe and effective administration of [liquid] medications; problems unremedied by pharmaceutical manufacturers, pharmacy intervention, or legacy drug-crushing devices. We have devised an innovative device and process capable of rapidly liquefying a majority of the solid drugs for enteral administration. The tabletop appliance would allow a caregiver close to the bedside to rapidly liquefy solid medications just prior to administration. Phase I has demonstrated feasibility of the method and apparatus. Phase II will continue engineering development of a prototype device, and assuring the chemical and pharmaceutical stability of liquefied drug products.

* Information listed above is at the time of submission. *

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