This project intends to study the feasibility of developing analytical procedures to be used for identifying the countryof origin of a given cannabis sample on the basis of its chemical profile. gas chromatography/mass spectrometry (gc/ms) will be the main technique used in the development of such… More

Studies in this proposal will be aimed at the preparation ofa suppository formulation of a pro-drug of delta-9-tetra- hydrocannabinol (^9-thc) and study the bioavailability of thc from this formulation as compared to i.v. administrationof both thc and its prodrug. bioavailability studies will be… More

Not Available Accurate Automation Corporation (AAC) will apply the latest knowledge in optimal control, adaptive control, and learning control to develop a state-of-the-art, adaptive, nonlinear, package for robust satellite guidance and control. The guidance module will generate an optimal… More

The development of maintenance treatment for subjects with addictive behavior is an important public health issue. Buprenorphine, a promising new drug for the treatment of opiates addition, has been widely abused since the mid-90's. Using drug testing for buprenorphine will become an important… More

DESCRIPTION (provided by applicant): The overall goal of this research project is to develop an effective, hot-melt extruded "Transmucosal Matrix Patch" (TMP) as a delivery system for Delta-9-Tetrahydrocannabinol (THC). THC will be incorporated into a stable, bioadhesive drug delivery system that is… More

DESCRIPTION (provided by applicant): The long term objectives of this proposal are aimed at the development of new composition(s) to be used for the prophylactic treatment/prevention of poison ivy contact dermatitis in sensitive individuals. Poison ivy/poison oak and another related species poison… More

DESCRIPTION (provided by applicant): Delta-9-Tetrahydrocannabinol (THC), the active ingredient in the cannabis plant, has a wide range of pharmacological properties of therapeutic value. The drug has been approved by the Food and Drug Administration (FDA) (Marinol(r) soft gelatin capsules) for the… More

DESCRIPTION (provided by applicant): Poison ivy/oak contact dermatitis is the most prevalent skin allergy in the United States, affecting gt50% of the adult population. The condition is the major cause of occupational hazard among outdoor workers in fores try, agriculture and firefighting,… More

DESCRIPTION (provided by applicant): Currently, FDA approved clinical applications of 9-Tetrahydrocannabinol (THC) include control of nausea and vomiting associated with chemotherapy and for appetite stimulation for AIDS patients suffering from anorexia and wasting syndrome. However, THC also… More