Not Available A high efficiency and precision control pneumatic/mechanical actuator which converts chemical to mechanical energy will extend human performance and provide advantages in reducing system weight and bulk. Quoin will analyze the concept of an actuator based on a central air compressor… More

Not Available There have been number of new technologies have been developed over the past decade to produce metallic and ceramic nanopowders, the market for which is growing rapidiv. However, much needed user-friendly characterization techniques for this new class of materials have not been… More

DESCRIPTION (provided by applicant): Phosphoinositides (PIPns), e.g., phosphatidylinositol 4,5-bisphosphate (PI 4,5) P2) are key signaling molecules in cellular communication. Specific PIPns recruit target signaling proteins and intracellular adapter proteins to inner… More

Phosphoinositides (PIP/nS), phospholipids (PLs), and sphingolipids (SLs) recruit signaling proteins and effectors to initiate signal transduction in response to internal and external signals.. Cellular processes such as endocytosis, protein sorting, cell proliferation, apoptosis, and cytoskeletal… More

Phosphoinositides are key lipid second messengers in cellular signaling. No approved diagnostics evaluate lipids as markers for cancer, but analysis of lipids in addition to protein and DNA may enhance overall accuracy of diagnosis and simultaneously suggest a molecular target for treatment. The… More

DESCRIPTION (provided by applicant): Isoprenoid compounds form a large ubiquitous class of natural products that fulfill a wide variety of essential cellular functions in al living organisms. In eukaryotes, isoprenoid compounds are synthesized by a mevalonate (MVA) dependent pathway. However, in… More

DESCRIPTION (provided by applicant): Phosphoinositide phosphates (PlPns) are important second messengers in signaling pathways controlling cellular proliferation, survival, morphology, and motility. Disruption of these pathways is common to many disease states, including diabetes, cardiovascular… More

Phosphoinositides are key lipid second messengers in cellular signaling. No approved diagnostics evaluate lipids as markers for cancer, but analysis of lipids in addition to protein and DNA may enhance overall accuracy of diagnosis and simultaneously suggest a molecular target for treatment. The… More

Phosphoinositides (PIPns), e.g., phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), are key signaling molecules in cellular communication. Specific PIPns recruit target signaling proteins and intracellular adapter proteins to inner membrane sites to activate protein kinases and thereby initiate… More

DESCRIPTION (provided by applicant): Protein kinases catalyze the phosphorylation of serine (Ser), threonine (Thr), and tyrosine (Tyr) residues in peptides and proteins, and comprise the largest superfamily of enzymes in eukaryotes with an estimated 500 genes in the human genome. Because most… More

DESCRIPTION (provided by applicant): Phosphoinositides (PIPnS) are integral signaling molecules for cellular communication. By recruiting specific proteins to the inner membrane, signal cascades are then initiated leading to downstream effects such as protein sorting, tumorigenesis, regulation of… More

DESCRIPTION (provided by applicant): Phosphoinositides are key lipid second messengers in many cellular signaling processes. In particular, the activity of phosphatidylinositol 3-kinase (PI 3-K), and the synthesis of its lipid products, is important in pathways mediating cell proliferation,… More

DESCRIPTION (provided by applicant): Isoprenoid compounds form a large ubiquitous class of natural products that fulfill a wide variety of essential cellular functions in all living organisms. In eukaryotes, isoprenoid compounds are synthesized by a mevalonate (MVA) dependent pathway. However, in… More

DESCRIPTION (provided by applicant): Phospholipids (PL) including phosphoinositides (PIPn) are crucial structural and signaling molecules for proper inter- and intra-cellular communication in an organism. The disruption of lipid homeostasis is associated with numerous human pathologies. High… More

DESCRIPTION (provided by applicant): Phosphoinositide recognition by binding proteins and lipid-metabolizing enzymes involves specific interactions with the head group and diacylglycerol backbone, which vary significantly from protein to protein. When a fluorescent probe is introduced into the… More

DESCRIPTION (provided by applicant): Isoprenoid diphoshates are key metabolic intermediates for the biosynthesis of many classes of molecules required by single and multicellular organisms. They fulfill a wide variety of cellular functions: components of cell membranes (sterols), electron transport… More

DESCRIPTION (provided by applicant): The long-term objective of this project is to identify a new class of antibiotics targeting the methylerythritol phosphate (MEP) pathway, a novel pathway essential for the viability of all Gram-negative and many Gram- p ositive bacteria. Gram-negative bacteria… More

DESCRIPTION (provided by applicant): Stroke has become a significant cause of mortality and morbidity among elderly people in industrialized countries. To address the growing burden of health care costs and the immeasurable emotional toll on families as we ll as affected individuals, new… More

DESCRIPTION (provided by applicant): Sphingolipids are a class of lipids that have important roles as structural components of cell membranes yet are also key signaling molecules involved in numerous cellular processes such as apoptosis, cell survival, dif ferentiation, motility, and growth. The… More

DESCRIPTION (provided by applicant): The long-term objective of this project is to identify a new class of antibiotics targeting an underexploited pathway essential for the viability of all Gram-negative bacteria, the methylerythritol phosphate (MEP) pathw ay. Gram-negative bacteria are responsible… More

DESCRIPTION (provided by applicant): Protein glycosylation plays very important roles in biological processes. However, detecting and differentiating such modifications rapidly is not a trivial issue. Therefore, developing novel tools that allow for the ra pid detection of glycosylation patterns is… More

This Small Business Innovation Research (SBIR) Phase I project aims to synthesize ATXRed, an in vivo imaging agent that is specifically activated by the enzymatic activity of autotaxin. Autotaxin is an extracellular enzyme that generates the phospholipid growth factor lysophophatidic acid (LPA). LPA… More

DESCRIPTION (provided by applicant): This project will help delineate the true nature of antigens in antiphospholipid syndrome (APS). Application of this knowledge would accelerate the pace of basic and clinical research as well as benefit tens of thousand s of U.S. patients each year. Primary… More

DESCRIPTION (provided by applicant): Protein glycosylation plays very important roles in biological processes. However, detecting and differentiating such modifications rapidly is not a trivial issue. Therefore, developing novel tools that allow for the rapid detection of glycosylation patterns is… More

DESCRIPTION (provided by applicant): Drug safety is a major concern for people that taking medicines as well as pharmaceutical companies, regulatory bodies, and basic researchers. Drug induced phospholipidosis (DIPL) is an adverse reaction to cationic amphiphilic drugs (CADs) resulting in excessive… More

This Small Business Innovation Research (SBIR) Phase II project aims to further develop ATX-Red, an in vivo imaging agent that becomes fluorescent in the presence of the enzyme autotaxin. Autotaxin and its product LPA are involved in numerous biological functions that generally involve cell… More

There needs to better biomarkers of alcohol consumption and alcohol induced organ damage. PEth is a nonoxidative, long-lasting metabolite of ethanol consumption and alcohol related organ damage. PEth may also play a role in cell and organ damage. In this contract antibodies are made to PEth for… More