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A HAND HELD ULTRASONIC METERED DOSE INHALER

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: N/A
Agency Tracking Number: 2R44HL056538-02A1
Amount: $0.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Timeline
Solicitation Year: N/A
Award Year: 2001
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
BOX 3073 JAMES FORRESTAL CAMPUS, BLDG 9A
PRINCETON, NJ 08543
United States
DUNS: N/A
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 ANDREW KAUFMAN
 () -
Business Contact
Phone: (609) 734-9282
Email: BARBARA@CONTINUUM-DYNAMICS.COM
Research Institution
N/A
Abstract

DESCRIPTION (Verbatim from the Applicant's Abstract): The objective of the
proposed effort is to develop a hand-held aerosol inhalation delivery system,
based on ultrasonic atomization, to replace or augment current metered dose
inhalers for both solutions and suspensions. Ultrasonic atomization produces
low velocity, monodispersed droplets, which provide excellent lung deposition.
The proposed device can deliver drugs for respiratory disease treatment, as
well as systemic application that take advantage of the lung's ability to
transfer molecules to the blood stream. Electronic control provides precise
dose control meet or exceed FDA regulations. Moreover, the ultrasonic-based
system does not require a propellant, which will help manufacturers eliminate
chlorofluorocarbon-based system and will simplify formulation of their
products. The feasibility of the system was demonstrated in Phase I by building
and testing a benchtop unit. The Phase II aims are to optimize the Phase I unit
by reducing its size and weight while increasing its efficiency. The optimized
prototype's performance will determined with solution and suspension
formulations in preparation for Phase III clinical trials. Measurements of drop
size distributions, drug delivery dose-to-dose repeatability, and atomization
rate as function of system parameters will be used to measure performance.

PROPOSED COMMERCIAL APPLICATION:
Not Available

* Information listed above is at the time of submission. *

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