The development of an advanced frequency-agile sensor for on-line chemical analysis of fluorescent species in process streams is the objective of this project. this sensor is based on the innovative use of tunable acousto-optic filters to achieve random-access wavelength selection with microsecond… More

Both passive and active tracking optical sensors, such as infrared seekers in hypersonic missiles, or laser pointing systems, require high angular precision. Vibration-induced distortion of optical components creates image distortions, image jitter, and can seriously degrade the performance of the… More

The effort is to develop a compact, simple-to-use, economic spectrophotometer based on the use of acoustooptic tunable filters as spectral selection elements. these acoustooptic devices will replace the conventional grating monochromators and will result in several significant improvements. a major… More

A compact, light weight, large area, high resolution two-dimensional real-time digital x-ray imaging system, based on the development of an integrated a-si:h photodiode array as image sensor is proposed. the first prototype image sensor will have a sensitive area 8" x 10" with 1024 x 1280 pixels… More

Tunable, acousto-optic filters (AOTF) for operation in the UV-VIS-IR spectral ranges are important elements in the design of advanced sensors for target acquisition, and discrimination. Their small size, random-access wavelength selection, rapid scan rates, and all solid-state construction with no… More

Researchers are developing a novel optical imaging system for studies of the nervous system. the concept is based on the use of acousto-optic tunable filters as spectral selection elements in a confocal fluorescence microscope. in conjunction with the use of multiply-labeled specimens, the… More

This phase i project offers an innovative approach to microsensing which is expected to result in compact, rugged, versatile, highly sensitive sensor systems capable of sophisticated on-line spectral analysis in a road class of chemical processes. these sensors would operate in real world factory… More

The proposed program contains two innovations to improve the useability of acousto-optic tunable filters (AOTF's). The first is the use of a phased array for the acoustic transducer to achieve acoustic wavefront steering. This will permit real-time control of bandwidth. The technique can be applied… More

Development of an advanced a spectroscopic sensor for on-line monitoring of hydraulic pump health status will be pursued. The proposed sensor will provide real-time information on wear status and will generate advance warning of impending catastrophic failure. If successful, the proposed technology… More

Under Ballistic Missile Defense Organization (BMDO) funding, Ciencia, Inc. has discovered a method to substantially improve a known spectral (and polarization) discrimination element, the acousto-optic tunable filter (AOFT). Ciencia's technology permits independent control of bandpass wavelength,… More

Electronically tunable optical filters are important components of freguency-agile sensor systems. Acousto-optic filters (AOTF) offer the best near-term technology for implementation of frequency-agile imaging optical sensors. These filters however, suffer from several limitations. On important… More

Fluorescence-lifetime based sensing provides a more robust and reliable detection method than intensity measurements which are notoriously prone to systematic errors. Measurement of fluorescence lifetime is also an important adjunct to quantitative spectrofluorimetric measurements in direct… More

We will use two approaches to produce new near infrared (nir) dyes for use as fluorescent probes for biological sensing. The first approach will build on the experience of the laboratory of Dr. Leslie Loew in the development of fluorescent dyes based on the aminostyryl pyridinium chromophore and… More

Development of an optical water level sensor is proposed to solve some of the problems and limitations of current sounding tube/protective well acoustic sensors. By using light instead of sound, temperature gradient effects on the measurement are obviated. Furthermore, the proposed system eliminates… More

50818-98-I Flourescence Detection of Latent Images--Ciencia, Inc., 111 Roberts Street, East Hartford, CT 06108-3653; (860) 528-9737 Dr. Salvador M. Fernandez, Principal Investigator Mr. Arturo O. Pilar, Business Official DOE Grant No. DE-FG02-98ER82553 Amount: $75,000 Current methods for… More

Development of an optical water level sensor is proposed to solve some of the problems and limitations of current sounding tube/protective well acoustic sensors. By using light instead of sound, temperature gradient effects on the measurement are obviated. Furthermore, the proposed system eliminates… More

Not Available The innovation offered by this Phase I SBIR proposal is a 2.488 Gbps spaceborne fiber optic network operating at ATM OC-48 data rates, with the potential of yielding interconnect speeds as high as 4.98 Gbps. This innovation represents a significant improvement in the data handling… More

The Space Station Biological Research Program at NASA is developing advanced facilities, including cell culture systems to conduct microgravity research in cell biology onboard the Space Station. These systems will provide basic and essential infrastructure for space-based cell biology research.… More

The Phase I objective is to develop a compact, low-cost, easy-to-use system for the rapid detection of Cryptosporidium oocysts. Two key innovations provide the foundation for Ciencia, Inc.'s system: (1) a dielectrophoretic field-flow-fractionation method to replace current filtering and… More

This Small Business Innovation Research (SBIR)Phase I proposed innovation is an optically addressable, dynamically reconfigurable, bi-directional, high-density, optical interconnect micro-array based on the phenomenon of grating-coupled surface plasmon resonance). The proposed device addresses the… More

The goal of this effort is to develop a novel label-free detection technology for application to protein microarrays. The objective of the Phase I is to build a breadboard prototype to characterize the performance of this new approach and to establish feasibility. The technology is based on a… More

This Small Business Innovation Research (SBIR)Phase I Project proposes to develop a microarray-based biosensor for on-site, real-time identification and enumeration of multiple environmental microorganisms from aqueous and/or aerosol samples with high sensitivity and specificity. The operation of… More

The Space Station Biological Research Program at NASA is developing advanced facilities, including cell culture systems to conduct microgravity research in cell biology onboard the Space Station. These systems will provide basic and essential infrastructure for space-based cell biology research.… More

The Space Station Biological Research Program at NASA is developing advanced facilities, including cell culture systems to conduct microgravity research in cell biology onboard the Space Station. These systems will provide basic and essential infrastructure for space-based cell biology research.… More

Rotating wall vessels (RWV) are widely used for cell culture in simulated microgravity conditions. Sensor technologies capable of monitoring the expression of proteins on a large scale (proteomics) are needed to fully exploit the unique capabilities of RWVs. This Phase II effort is part of a program… More

Rotating wall vessels (RWV) are widely used for cell culture in simulated microgravity conditions. Sensor technologies capable of monitoring the expression of proteins on a large scale (proteomics) are needed to fully exploit the unique capabilities of RWVs. This Phase II effort is part of a program… More

A microarray-based system for label-free, high throughput protein expression in profiling in very small volumes of tissue or blood (approximately 10 mL) is proposed. The system will consist of an instrument, and a proteomic biosensor chip integrated into a fluidics cartridge. It utilizes a novel… More

DESCRIPTION (provided by applicant)The broad objective of this Fast Track project is to develop and commercialize a versatile and inexpensive CCD-based system for microarray imaging and quantification. A differentiating feature of this system will be the capability to perform time-gated imaging,… More

The objective of the proposed effort is to develop a novel technology that will provide a unique and powerful alternative to conventional flow cytometry. This new system, which we call a cytometer on a chip will spatially sort cells on a microarray chip based on the presence of specific cell surface… More

The objective of the proposed program is to develop a portable, low-cost, label-free (reagentless), microarray system capable of near real-time simultaneous detection and identification of multiple analytes (bacteria, viruses, spores, toxins) with highsensitivity and low false alarm rate. Notably,… More

This Small Business Innovation Research Phase II project will develop a portable system for real-time, simultaneous detection and identification of multiple environmental microbes and toxins from aqueous or aerosol samples, on site, with high sensitivity and specificity and with minimal false… More

The Cytometer on a Chip will provide a powerful alternative to conventional flow cytometry. This system spatially sorts cells on a microarray chip based on the presence of specific cell surface markers. Detection is accomplished with grating-coupled surface plasmon resonance imaging (GCSPRI). This… More

DESCRIPTION (provided by applicant): The goal of the proposed effort is to develop a biosensor for rapid, on-site measurement of chemical environmental contaminants. The crux of the innovation is to use grating-coupled surface plasmon resonance (GCSPR) transduction in conjunction with a microarray… More

The objective of the proposed program is to develop a portable, low-cost, label-free (reagentless), microarray system capable of near real-time simultaneous detection and identification of multiple analytes (bacteria, viruses, spores, toxins) with high sensitivity and low false alarm rate. Notably,… More

The objective of the proposed program is to develop a portable, low-cost, label-free (reagentless), microarray system capable of near real-time simultaneous detection and identification of multiple analytes (bacteria, viruses, spores, toxins) with high sensitivity and low false alarm rate. Notably,… More

DESCRIPTION (provided by applicant): The objective of this Phase I project is to test the feasibility of biochip imaging system which will vary the temperature of the arrays and perform real-time imaging and quantification during PCR and probe meltoff. A specialized microarray of discrete hydroge!… More

DESCRIPTION (provided by applicant): The long term objective of the proposed project I is to develop an affordable, highly parallel and highly sensitive detection system for protein and DMA chip applications. This system is based on a novel fluorescence detection technology with the potential for… More

DESCRIPTION (provided by applicant): The objective of this SBIR Phase II project is to develop a novel fluorescence detection technology for highly parallel microarray analysis that will provide dramatically increased fluorescence signals so that high-sensitivity detection can be achieved with an… More

We propose to develop an innovative biosensor system for near real time, on-line monitoring of water for the presence of pathogens and biotoxins. The proposed optical biosensing approach possesses a unique combination of features that make it ideal for meeting the requirements of a water analysis… More

DESCRIPTION (provided by applicant): The long-term objective of the proposed effort is to develop an autonomous clinical diagnostics system for monitoring normal and diseased immune function that occurs in the context of infection, inflammation, asthma, au toimmune disease, and neoplasia. This… More

DESCRIPTION (provided by applicant): The diagnosis of rheumatoid arthritis (RA) and other autoimmune disease is a complex challenge that combines the interpretation of a range of physiological cues and molecular assays. Traditionally, radiography has been used to measure RA progression. In vitro… More

DESCRIPTION (provided by applicant): Type 1 Diabetes (T1D) affects more than 1 million people in the United States and is usually diagnosed in children and can lead to blindness, heart disease and kidney failure. A major focus of intervention for T1D is on the detection and characterization of… More

DESCRIPTION (provided by applicant): The long-term objective of the proposed effort is to develop an autonomous clinical diagnostics system for monitoring normal and diseased immune function that occurs in the context of rheumatoid arthritis, infection , inflammation, asthma, autoimmune disease,… More

DESCRIPTION (provided by applicant): Type 1 Diabetes (T1D) affects more than 1 million people in the United States Source ADA http://www.diabetes.org/about-diabetes.jsp and is usually diagnosed in children and can lead to blindness, heart disease and kidney failure. A major focus of intervention… More

DESCRIPTION (provided by applicant): The proposed work will result in a characterized prototype instrument that will facilitate the identification of a broad range of analytes in small volumes of human blood, urine, saliva and other readily obtainable biological fluids with little sample… More

DESCRIPTION (provided by applicant): The objective of this Phase I SBIR proposal is the development of a novel instrumentation platform based on Surface Plasmon Resonance (SPR) that if validated would greatly increase the utility of this label-free technology to researchers utilizing high-content… More

DESCRIPTION (provided by applicant): Polymicrobial infections are of great concern to the research community because they have a dramatic impact on the productivity research groups, on the reliability of experimental results, and on the progress that can be made in unraveling fundamental biological… More