You are here

A Biomechanical-Physiological Model for Preclinical Investigation of Blast Wave TBI

Award Information
Agency: Department of Defense
Branch: Army
Contract: W81XWG-09-C-0043
Agency Tracking Number: O083-H14-3026
Amount: $99,912.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: OSD08-H14
Solicitation Number: 2008.3
Timeline
Solicitation Year: 2008
Award Year: 2009
Award Start Date (Proposal Award Date): 2009-01-20
Award End Date (Contract End Date): 2009-08-29
Small Business Information
215 Wynn Dr., 5th Floor
Huntsville, AL 35805
United States
DUNS: 185169620
HUBZone Owned: No
Woman Owned: Yes
Socially and Economically Disadvantaged: No
Principal Investigator
 Andrzej Przekwas
 Senior Vice President, Research
 (256) 726-4800
 tsb@cfdrc.com
Business Contact
 Deborah Phipps
Title: Contracts Specialist
Phone: (256) 726-4800
Email: dap@cfdrc.com
Research Institution
N/A
Abstract

Recent statistics from Operation Iraqi Freedom (OIF) show that 61% of soldiers injured in explosion blast events endure Traumatic Brain Injury (TBI). The current understanding of TBI mechanisms is incomplete and is limiting the development of protection and therapeutic measures. Animal testing, in vitro study, and analysis of clinical data are useful and necessary but these are slow, expensive, and often inconclusive. Anatomy and physiology based mathematical modeling tools of blast brain injury to small animals will provide complementary capabilities for a better understanding of blast wave brain injury mechanisms, assessing and improving protective armor, and faster development of better treatment protocols. The overall objective of this project is to develop and validate high-fidelity and reduced order multiscale modeling tools for the analysis of blast wave primary TBI mechanisms in animal models. In Phase I we will develop a “virtual rat” model of blast wave TBI and adapt the multiscale computational tools for parametric simulations of three-way coupled shock wave – whole body biomechanics – vascular response to shock waves. The model will be validated against available data from shock tube experimental tests. In Phase II we will develop virtual mouse and pig models. The modeling tools and the experimental data will be used to develop brain injury criteria and methodology for animal-to-human scaling.

* Information listed above is at the time of submission. *

US Flag An Official Website of the United States Government