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FISH ASSAY FOR THE DETECTION OF T (14;18) (Q32;21)
Phone: () -
Email: ED@CANCERGENETICS.COM
DESCRIPTION (applicant's abstract): Approximately 60 percent of B-cell
lymphomas are characterized by the presence of the t(14;18) (q32;q21)
chromosomal translocation. Diagnosis and post-treatment follow-up are currently
performed by karyotype, Southern blotting, or PCR, which have problems with
specificity and sensitivity. Fluorescence in situ hybridization (FISH)
addresses these limitations; however, no clinically tested FISH probes are
available for detecting the t(14; 18) translocation. Phase I research developed
novel probes for interphase FISH analysis of the t(14; 18) translocation. Using
both normal and tumor samples, high sensitivity and specificity of the probes
were observed. Using tumor specimens from multiple tissue types, Phase II
research will validate use of the probes for diagnosis. Phase II research will
also validate their use for monitoring minimal residual disease. In Phase II
research, the probes will also be optimized to reduce background hybridization
signal.
PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE
* Information listed above is at the time of submission. *