Development of a Portable Breath Analysis System Based on a Novel Electronic Nose Microsensor

Significant recent research has shown that breath biomarkers are excellent indicators of oxidative stress caused by conditions ranging from radiation exposure to COPD. Current techniques for collection, concentration, and analysis of exhaled breath do not support real-time analysis, or require complex and bulky equipment. Streamline Automation, LLC will develop a portable Breath BioDetector in partnership with Argonne National Laboratory. The core technology is ANL's Electronic Nose Microsensor, a robust sensor, about the size of a postage stamp, that is capable of simultaneously detecting gases at low concentrations. The small size, and multi-gas capability of the sensor enables integration into a compact, light weight, portable system. Streamline Automation's system design and integration experience will be augmented with the clinical experience of Dr. Keary Cope, USDA, and Dr. Bruce Freeman, UAB. They will assist in developing the requirements for the prototype Breath BioDetector and the protocol for its use. During Phase 2, Dr. Freeman will test prototype units in conjunction with a 5-year NIH grant to study NO as a breath biomarker for COPD. This testing will provide valuable clinical experience that would not otherwise be possible during a Phase 2 project.