THE FABRICATION OF MULTIELECTRODES FOR CHRONIC, SIMULTANEOUS RECORDING OF SINGLE NEURONS IN TISSUE CULTURES, PERIPHERAL NERVES, HIPPOCAMPUS, AND CEREBRAL CORTEX HAS PROGRESSED TO THE POINT WHERE THE VOLUME OF SINGLE-UNIT DATA IS NOW SIGNIFICANT.

THE FABRICATION OF MULTIELECTRODES FOR CHRONIC, SIMULTANEOUS RECORDING OF SINGLE NEURONS IN TISSUE CULTURES, PERIPHERAL NERVES, HIPPOCAMPUS, AND CEREBRAL CORTEX HAS PROGRESSED TO THE POINT WHERE THE VOLUME OF SINGLE-UNIT DATA IS NOW SIGNIFICANT. RECENT ADVANCES IN SIGNAL PROCESSING ARE BEING USED BY BTS TO DEVELOP IMPROVED METHODS OF EXTRACTING SINGLE-UNIT ACTIVITY. ADVANCES IN AREAS SUCH AS FEATURE EXTRACTION, ADAPTIVE FILTERING, CLUSTER ANALYSIS, AND SPIKE SORTING WITH AUTOMATIC TRACKING THE RESULT EXPECTED FROM OUR PHASE I EFFORTS WILL BE A NUMBER OF FEASIBLE DESIGNS FOR A MULTICHANNEL SPIKE SORTER THAT IS ABLE TO ADAPT TO TIME-VARYING SPIKE WAVEFORM PARAMETERS. INITIAL PHASE II EFFORTS WILL BE TO SELECT THE BEST DESIGN VIA COMPUTER MODELING OF THE DETECTION AND CLASSIFICATION ALGORITHMS FROM PHASE I RESEARCH. A HARDWARE PROTOTYPE WILL THEN BE BUILT AND TESTED USING REAL DATA.