Not Available There is a need in both commercial and military applications for digital transmission methods that can operate at high data rates (several megabits per second end-user rate) in multi-user environments. Existing communication methods will be severely stressed by the requirements of… More

DESCRIPTION (provided by applicant): The goal of this Phase II Competing Continuation research project is to complete the Phase I clinical trial of a new magnetic resonance imaging guided minimally invasive treatment for focal brain tumors. Over the past four years, BioTex has developed the… More

DESCRIPTION ( Investigator's Abstract): The goal of this research is the development of a highly maneuverable, self-propelled gastrointestinal intervention system. The technology developed under this program is intended to greatly expand the range of diagnostic and therapeutic procedures… More

DESCRIPTION: (Verbatim) - In recent years, the popularity of tattooing has grown tremendously with over 10 million Americans now believed to have one or more tattoos. Along with this demand for tattoos comes an increased demand for tattoo removal. A limitation of laser tattoo… More

DESCRIPTION: Currently under development is a novel optical probe for non-invasive characterization and monitoring of the biochemical and morphological changes in oral cavity epithelium leading to dysplasia and ultimately to invasive squamous cell… More

DESCRIPTION (provided by applicant): The liver and brain are the most common sites of metastatic tumors. At the time of death, approximately two-thirds of patients with colorectal cancer have liver metastases. In addition approximately 83 percent of all brain cancers will be diagnosed as… More

DESCRIPTION (provided by applicant): Approximately 13,000 cases of invasive cervical cancer will be diagnosed in the United States, in 2002, and approximately 4,100 women will die from the disease. The 5-year relative survival rate for the earliest stage of invasive cervical cancer is 91%. The… More

DESCRIPTION (provided by applicant): Approximately 30-70% of all cancer patients will eventually experience tumor metastasis to the spine. Such tumors are often excruciatingly painful and debilitating to the patient. Treatment strategies for metastatic spinal lesions are palliative in nature and are… More

DESCRIPTION (provided by applicant): The focus of this research is to continue development of a device and technique for dermal clearing which will improve the efficacy of laser tattoo removal and other dermatological laser procedures including treatment of port wine stain and telangiectasia and… More

DESCRIPTION (provided by applicant): At least 65,000 cancer patients will develop symptomatic spinal metastatic lesions this year. Additionally, approximately 30-70% of all cancer patients exhibit spinal metastasis at autopsy indicating that the prevalence of problematic spinal tumors will increase… More

DESCRIPTION (provided by applicant): Approximately 190,000 new cases of prostate cancer will be diagnosed in the U.S. in 2003, and this year 30,400 American men will die from prostate cancer. In the United States, the annual cost of treating prostate cancer has reached $1.72 billion. While there are… More

DESCRIPTION (provided by applicant): Approximately 190,000 new cases of prostate cancer will be diagnosed in the U.S. in 2003, and this year 30,400 American men will die from prostate cancer. In the United States, the annual cost of treating prostate cancer has reached $1.72 billion. While there are… More

The focus of this research project is to design and evaluate a first-generation prototype of a wearable fluorescence detector and display device for transdermal glucose monitoring. The unique feature of the detector and readout device is its high specificity and selectivity for the glucose… More

DESCRIPTION (provided by applicant): Diabetes mellitus is a metabolic disease, which currently afflicts some 16 million in the US and 100 million people worldwide. In the US, diabetes and its associated complications are the seventh leading cause of death. Effective management of diabetes… More

DESCRIPTION (provided by applicant): The focus of this research is to continue development of a novel interstitial cooled laser delivery system for improved thermal therapy. The system is intended to find applications in the thermal destruction of cancerous tumors. Laser interstitial thermal… More

DESCRIPTION (provided by applicant): Diabetes mellitus is a metabolic disease which currently afflicts some 16 million in the US and 100 million people worldwide. In the US, diabetes and its associated complications are the seventh leading cause of death. Effective management of diabetes requires… More

DESCRIPTION (provided by applicant): The goal of this Phase II Competing Continuation research project is to complete the Phase I clinical trial of a new magnetic resonance imaging guided minimally invasive treatment for focal brain tumors. Over the past four years, BioTex has developed the… More

DESCRIPTION (provided by applicant): We will continue development of a novel optical probe for non-invasive characterization and monitoring of the biochemical and morphological changes in oral cavity epithelium leading to dysplasia and ultimately to invasive squamous cell carcinoma. Oral squamous… More

The unique stresses in the spacecraft environment including isolation, containment, weightlessness, increased radiation exposure, and enhanced microbial contamination have resulted in a compromise of the immune system in every human or animal that has ever flown in space. Identifying and monitoring… More

Rapid, exploratory diagnostics are needed for the identification of bacteria in complex food and water samples. This project focuses on development of a novel, rapid system for molecular identification of bacteria.

DESCRIPTION (provided by applicant): The goal of this Phase I project is to develop a first-generation prototype interstitial glucose sensor designed for 3 to 5 day monitoring in diabetic patients. We have previously demonstrated the success of a fluorescence (FRET-based) approach with an improved… More

DESCRIPTION (provided by applicant): The World Health Organization estimates that over 1,600 people die each hour from an infectious disease, half of whom are children under 5 years of age. Infectious diseases account for 26 percent of total global mortali ty and are the third leading cause of death… More

DESCRIPTION (provided by applicant): There is an urgent need for a long-term in vivo glucose-monitoring device for diabetes therapy. Diabetes is currently believed to afflict over 100 million people worldwide and nearly 18 million in the United States. In the U.S. this disorder, along with its… More

This proposed project directly addresses an U.S. Environmental Protection Agency (EPA) calling for improved detection and measurement techniques including screening kits for algal neurotoxins (especially cyanobacterial anatoxin) and cytotoxins in drinking water systems. Bloom-forming cyanobacteria… More

This Small Business Technology Transfer Phase I project develops molecular biology, biochemical engineering, and purification techniques to provide small interfering RNA or siRNA molecules on at large-scale and at low cost compared to available techniques. In recent years, siRNA's have been… More

DESCRIPTION (provided by applicant): The goal of this Phase I proposal is to explore the technical feasibility of minimally invasive ultrasound-guided laser ablation of symptomatic thyroid nodules. Under previous SBIR support, we have developed a cooled la ser delivery system for improved laser… More

DESCRIPTION (provided by applicant): Because of the large amount of genetic information which can be rapidly accessed, DNA microarrays have become indispensable tools for biological investigations. Despite their utility, however, a number of experimental d ifficulties have resulted in widely varying… More

DESCRIPTION (provided by applicant): Bioremediation technologies use microorganisms to reduce, eliminate, contain, or transform to benign products contaminants present in soils, sediments, water, and air. While biological treatment of domestic and industri al waste has been employed for some time,… More

DESCRIPTION (provided by applicant): Aptamers have emerged as one of the most promising classes of drug leads and diagnostic ligands presently available. Aptamers, nucleic acid ligands derived from large combinatorial libraries, typically have affinities a nd specificities that rival antibodies, yet… More

DESCRIPTION (provided by applicant): The World Health Organization estimates that over 1,600 people die each hour from an infectious disease, half of whom are children under 5 years of age. Infectious diseases account for 26 percent of total global mortali ty and are the third leading cause of death… More

DESCRIPTION (provided by applicant): There is an urgent need for a long-term in vivo glucose-monitoring device for diabetes therapy. Diabetes is currently believed to afflict over 100 million people worldwide and nearly 18 million in the United States. In the U.S. this disorder, along with its… More

DESCRIPTION (provided by applicant): Diabetes is currently believed to afflict over 100 million people worldwide and nearly 18 million in the United States. In the U.S. this disorder, along with its associated complications, is ranked as the seventh leadin g cause of death. To significantly improve… More

DESCRIPTION (provided by applicant): Current focus in improving acceptance of implants is to engineer materials that proactively control the interaction of the material surface with the biological milieu. Such control could ultimately lead to implants with long-term operational functionality due to… More

DESCRIPTION (provided by applicant): The goal of this Phase I SBIR proposal is to develop a navigation and image fusion system for improved diagnosis of cervical cancers and pre-cancers. The system will combine optical coherence tomography (OCT) imaging wi th traditional colposcopy (with or without… More

DESCRIPTION (provided by applicant): The importance of in vivo small animal research to the scientific community cannot be overestimated. Along with the advantages of small animal manipulations come inherent difficulties, among them intubations which are o ften necessary for inhalation anesthesia.… More

DESCRIPTION (provided by applicant): The goal of this Phase I SBIR Grant Proposal is to develop a new device and methodology for local elevation of a target tissue's temperature prior to a planned thermal ablation, a process we've dubbed hyperablation . I n preliminary work we demonstrated that… More

Thousands of antibodies are produced every year by commercial companies. However, many of these antibodies are known to be poorly characterized and suboptimal across multiple applications. Polyclonal  antibodies lack the reproducibility of monoclonal antibodies. Likewise, the production of… More

DESCRIPTION (provided by applicant): Asthma afflicts as many as 39 million Americans and some 4,000 will die of the disease each this year. The goal of this Phase I SBIR proposal is to design, develop, build, and test a novel, cooled laser catheter for effecting Bronchial Thermoplasty in a safe and… More

DESCRIPTION (provided by applicant): Aptamers have emerged as one of the most promising classes of drug leads and diagnostic ligands presently available. Aptamers, nucleic acid ligands derived from large combinatorial libraries, typically have affinitiesand specificities that rival antibodies, yet… More

The carbohydrate modification O-GlcNAc is nearly as abundant as protein phosphorylation in proteins, competes with it, and has extensive crosstalk to regulate signaling, transcription, and the functions of oncogenes and tumor suppressors. However, analysisof protein O-GlcNAcylation currently… More

DESCRIPTION (provided by applicant): The goal of this Phase II SBIR project is to continue development of an exciting platform based on integration of optical coherence tomography acquisition with real-time 3D spatial localization. In Phase I, in the context of gynecological diagnostic imaging, we… More

DESCRIPTION (provided by applicant): The objective of the phase I proposal is to demonstrate the feasibility of a new and innovative insulin assay for its integration in a small benchtop device with the focus in clinical diabetes therapy: A) for assessmentof insulin impairment in type II diabetics,… More

DESCRIPTION (provided by applicant): The World Health Organization estimates that diabetes affects about 185 million people worldwide, with approx. 20 million individuals (approx. 6 percent by population) afflicted in the US (approx. 10 percent of this type 1 diabetes). Tighter glucose control… More

DESCRIPTION (provided by applicant): Project Summary The goal of this NIH-SBIR Phase I proposal is to develop a new point-of-care (POC) detection platform and methodology for assessment of human exposure to hazardous environmental compounds in the bloodstream. Because the mechanisms of transport of… More

DESCRIPTION (provided by applicant): The goal of this Phase I SBIR application is to develop a new minimally invasive therapy for laser ablation of epileptogenic seizure foci. There is a large unmet need for better treatment options for the nearly one million epilepsy patients in the U.S. that are… More

Thousands of antibodies are produced every year by commercial companies. However, many of these antibodies are known to be poorly characterized and suboptimal across applications. Polyclonal antibodies lack the reproducibility of monoclonal antibodies. Theproduction of monoclonal antibodies is… More