Removal of dental calculus remains a major consumer expense of oral health care. products designed to inhibit supra- gingival calculus formation may have adverse effects on hostmineral metabolism, as biologic calcification occurs by similar processes in animals and bacteria. diphosphonates and… More

The long-term goal of this application is to develop dimethylsuberimidate (dms) as an alternative pulp therapy. formocresol, the drug most commonly used for treatment of cariously exposed pulps of the primary dentition, is toxic to the treated tissue, induces antigen formation and subsequent chronic… More

The research in this project will test the appropriateness of using immunotherapy for prevention of dental calculus. an in vitro model of microbial calcification will be used.

The purpose of this research is to fabricate and test the efficacy of culture dishes with unique surfaces. thin filmsof metal, metal alloys and ceramics will be applied to standard polystyrene culture dishes. growth of fibroblast and osteoblast cell lines on the culture plates will serve as models… More

Rotational panoramic radiography is a well-established radiographic technique that is widely used in dentistry. this technique displays the entire maxillomandibular region on a single film. with the development of digital computers and suitable radiation detectors, it has become possible to develop… More

Currently, poultry products which are processed and distributed in a non-cooked form, may contain significant numbers of pathogenic bacteria such as salmonella, listeria and campylobacter. poultry processing technology has not at this time developed a system of evisceration that does not contaminate… More

Currently, poultry products which are processed and distributed in a non-cooked form, may contain significant numbers of pathogenic bacteria such as salmonella, listeria and campylobacter. poultry processing technology has not, at this time, developed a system of evisceration that does not… More

Immunologic rejection is the leading cause of failure of renal transplantation. the objective will be to develop an assay for monitoring kidney transplant recipients for the onset of graft rejection and to help distiguish graft rejection from other renal and extrarenal problems in these patients.… More

We are developing a cold sterilization technology that is rapidly biocidal against fungi, viruses, bacteria and bacterial spores, but is neither toxic nor mutagenic to higher organisms.the biocidal activity remains potent for long periods of time, is non-corrosive to 200 and 400 grade stainless… More

We will develop and test a locating device worn on a person's body that can be used to locatepatients with dementia who have wandered away. Current technology used to protect wanderingpatients focuses on alerting caregivers to patient exits, but does not assist in locating patients once theyhave… More

Formaldehyde is a common disinfecting agent in dialyzer membrane reuse procedures. Since formaldehyde is carcinogenic, toxic and malodorous, any safe, cost-effective alternative would be a marketable an medical success. The long-term objective is to benefit patient care, employee safety, and cost… More

The investigator is developing Enzocide for use in the egg processing industry. The incidence of fooutbreaks associated with Salmonella has risen steadily since the mid 1970s. The monetary cost of saestimated at 4 billion dollars, annually. The primary cause of salmonellosis has been linked to… More

The observed antigenic cross-reactivity between the Borrelia species that causes Lyme disease and Bthat causes Relapsing Fever is one of the problems in confirming cases of Lyme disease in areas endeinfections. As thedemand for the development of Lyme disease diagnostic procedures increases, it isbe… More

Chronic bladder and bowel incontinence are a major clinical problem among the aged. Skin break downwhen the highly corrosive urine or liquid stool remains on the skin. Skin irritation such as perineaminutes of initial exposure to caustic substances, and certainly over time with repeated or… More

The incidence of food borne outbreaks associated with Salmonella has risen steadily since the mid1970's. The monetary cost of salmonellosis has been estimated at $4 billion annually. The primarycause of salmonellosis has been linked to the consumption of eggs or egg products containingSalmonella… More

We are developing a powdered cold sterilization technology that is rapidly biocidal against bacteriand bacterial and fungal spores, but is neither toxic nor mutagenic to higher organisms. The biocidafor extended periods, is non- corrosive to 200 and 400 grade stainless steel, does not stain or… More

Mastitis costs the average U. S. dairy farmer approximately $180 per cow annually in lost milk production, cost of antibiotic treatment, and discarded milk. Unfortunately, the disease is obvious only in the clinical form. Subclinical mastitis is about 15 to 40 times more prevalent and accounts for… More

Not Available Mastitis costs the average U. S. dairy farmer approximately $180 per cow annually in lost milk production, cost of antibiotic treatment, and discarded milk. Unfortunately, the disease is obvious only in the clinical form. Subclinical mastitis is about 15 to 40 times more prevalent and… More

Not Available HYPRES proposes to develop a novel passive, millimeter-wave imager (PMWI) of much lower cost than competing types. The PN1WI will employ a staring array of micromachined detectors, each coupled to its own thin-film antenna and feedhorn. Until the present, the sensitivity of such a… More

Not Available The ability to form images through densely scattering media has been highly desirable in medical diagnostics. The gating approach utilizes the principle that scattered light will travel farther than unscattered, ballistic light. A laser, with a very short pulse width or coherence… More

DESCRIPTION (Provided by the applicant): The goal of this project is to establish the safety and efficacy of a unique drug delivery system for use as a sustained-release, antifungal skin preparation for the treatment of superficial mycoses. The lifetime risk of acquiring a… More

DESCRIPTION (provided by applicant): The goal of this project is to demonstrate the feasibility of using a novel technology as a dual purpose wound dressing and drug delivery vehicle for the treatment of wounds associated with early stage diabetic foot ulcers. Diabetes is the… More

DESCRIPTION (Provided by applicant): Hemodialysis-related infections and adverse patient outcomes continue to be associated with contaminated fluids often arising from biofilm formation in the tubing of hemodialysis systems. Currently available reagents to disinfect fluid delivery lines are… More

DESCRIPTION (Provided by applicant): Hemodialysis-related infections and adverse patient outcomes continue to be associated with contaminated fluids often arising from biofilm formation in the tubing of hemodialysis systems. Currently available reagents to disinfect fluid delivery lines are… More

Description(provided by applicant): Candida is the third leading cause of catheter-related nosocomial bloodstream infections. Indwelling devices have been shown to support colonization and biofilm formulation by Candida. Intravenous lines are the most frequent indwelling device and are the… More

DESCRIPTION (provided by applicant): Topical corticosteroids are useful treatment modalities for numerous dermatologic conditions. Most topical corticosteroids are applied in a cream or ointment vehicle, which require multiple applications, are subject to inadvertent removal, and can be… More

DESCRIPTION (provided by applicant): The goal of this project is to develop a polymer-based vehicle for the topical delivery of caffeine to inhibit UV-induced skin cancer. Despite increased use of sun screen, skin cancer rates continue to rise. Recently, caffeine has been shown to inhibit… More

DESCRIPTION (provided by applicant): The goal of this project is to complete the development of a unique, non-toxic thin film technology to be used as a skin barrier that is worn underneath surgical and examination gloves. The efficacy of gloves has become an important issue, especially for… More

DESCRIPTION (provided by applicant): The goal of this project is to complete the development of a unique, non-toxic thin film technology to be used as a skin barrier that is worn underneath surgical and examination gloves. The efficacy of gloves has become an important issue, especially for… More

DESCRIPTION (provided by applicant): The overall goal of this proposal is to develop Iocide(r), a unique non-toxic, non-staining mouthrinse to treat gingivitis. Antimicrobial mouthrinses are valuable supplements to normal oral hygiene procedures and have demonstrated their ability to control plaque… More

DESCRIPTION (provided by applicant): The overall goal of this proposal is to develop Iocide(r), a unique non-toxic, non-staining mouthrinse to treat gingivitis. Antimicrobial mouthrinses are valuable supplements to normal oral hygiene procedures and have demonstrated their ability to control plaque… More

DESCRIPTION (provided by applicant): Poison ivy/oak dermatitis (also known as Toxicodendron dermatitis) is the most common allergic contact dermatitis in the United States, affecting millions of Americans every year. The prevalence of poison ivy and oak sensitivity in the general adult… More

DESCRIPTION (provided by applicant): Treatment of hypertrophic scars and keloids is time consuming, expensive, and has few consistently successful approaches. Hypertrophic scars and keloids are often treated with intralesional injection, pressure therapy, or excision. Unfortunately, these… More

DESCRIPTION (provided by applicant): The goal of this project is to develop a novel topical drug delivery vehicle to treat postherpetic neuralgia [PHN). PHN is defined as pain in the affected dermatome that persists or appears after the rash of herpes zoster (HZ) has healed. Although many cases of… More

DESCRIPTION (provided by applicant): The goal of this project is to develop a unique, safe and efficacious mouth rinse to treat oral candidiasis in patients with cancer. Oral candidiasis or oral thrush is a disease caused by all species of the fungus Candida and is a common infection for… More

DESCRIPTION (provided by applicant): Disorders of keratinization are a heterogeneous group of diseases characterized by dry and scaly skin that demonstrate changes in the biophysical properties of the stratum corneum, especially with respect to the water permeability barrier. These diseases, also… More

DESCRIPTION (provided by applicant): Oral candidiasis (oropharyngeal candidosis or thrush) is a common infection in immunosuppressed individuals, and, if not blunted, can transit to esophageal candidosis or life-threatening candidemia. These potentially life-threatening fungal infections originate… More

DESCRIPTION (provided by applicant): Irritant and allergic contact dermatitis affect approximately 10% of adults, and hand eczema represents one of the four most common occupationally related diseases, accounting for substantial lost earning potential in otherwise healthy populations. Both irritant… More

DESCRIPTION (provided by applicant): The goal of this project is to develop a safe biocidal vaginal gel for treatment of vulvovaginal candidiasis (WC). WC is caused by one of several airborne species of the yeast Candida that are normal inhabitants of humans at several sites, including the vagina.… More

DESCRIPTION (provided by applicant): Otitis media is a common childhood disease with annual direct costs estimated to exceed 3 billion. Otitis media is the most frequent cause of pediatric practitioner visits and results in more than 20 million antibiotic prescriptions annually. However, the… More

DESCRIPTION (provided by applicant): Urinary tract infections (UTIs) are very common bacterial infections that affect millions of people each year. In the U.S., approximately 10% of women are diagnosed with cystitis annually, with an associated cost of 1. 6 billion. UTIs are also the most commonly… More

DESCRIPTION (provided by applicant): Periodontal disease has been recently identified as a risk factor for increased morbidity and mortality for systemic diseases such as pancreatic cancer, cardiovascular disease (atherosclerosis, myocardial infarction, a nd stroke), and diabetes, as well as for… More

DESCRIPTION (provided by applicant): Periodontal disease has been recently identified as a risk factor for increased morbidity and mortality for systemic diseases such as pancreatic cancer, cardiovascular disease (atherosclerosis, myocardial infarction, a nd stroke), and diabetes, as well as for… More

DESCRIPTION (provided by applicant): Bipolar disorder is an inherently complex chronic illness characterized by recurrent, dramatic mood changes. Management of bipolar disorder typically consists of a combination of medication, therapy, and lifestyle adjustments. However, clinicians lack tools to… More

DESCRIPTION (provided by applicant): Deep wound infection following total joint arthroplasty is a devastating complication for physician and patient, a leading cause of morbidity, and a significant economic burden to the healthcare system. With an aging population and increased life expectancies,… More

DESCRIPTION (provided by applicant): Despite years of research, the cause of Alzheimer's disease remains essentially unknown. Topographic memory impairments are arguably the earliest cognitive deficits observed in Alzheimer's disease, and the brain areas involved in topographic memory are… More